Results 101 to 110 of about 37,088 (271)

Quantitative aspects of interorgan relationships among arginine and citrulline metabolism

, 1996
The quantitative roles of the splanchnic region and the kidneys in whole body (WB) arginine and citrulline metabolism were assessed in postabsorptive mongrel dogs with primed constant intravenous infusions of [15N2-guanidino, 5,5-2H2]arginine and [13C ...
Y. M. Yu, V. R. Young, R. Martin, J. F. Burke, R. G. Tompkins   +4 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Tolerogenic citrullinated peptide for arthritis

Oncotarget, 2015
Disease-specific autoantibodies directed against post-translation citrullinated proteins/peptides (ACPAs) are specific serological markers for rheumatoid arthritis (RA) and have been accepted as one of the classification criteria for the disease. Beyond diagnosis these autoantibodies have also been shown also to predict disease severity.
Smadar, Gertel, Yehuda, Shoenfeld, Howard, Amital   +2 more
openaire   +2 more sources

Plasma Citrulline in the Diagnosis and Follow-Up of Celiac Disease

Children
Background/Objectives: Citrulline, an amino acid produced by small bowel enterocytes, has been proposed as a potential marker of intestinal absorptive capacity.
Alicia Isabel Pascual Pérez, Elene Larrea Tamayo, Santiago Jiménez Treviño, David González Jiménez, David Pérez Solís, Cristina Molinos Norniella, Juan José Díaz Martín   +6 more
doaj   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Plasma citrulline kinetics and prognostic value in critically ill patients.

, 2010
International audiencePURPOSE: Multiple organ failure is a leading cause of death in critically ill patients and could be secondary to early gut ischemia.
Barbot, Olivier, Carbonnel, Franck, Monnet, Elisabeth, Cypriani, Benoit, Capellier, Gilles, Piton, Gaël, Navellou, Jean-Christophe, Manzon, Cyril   +7 more
core   +1 more source

Protective Effects Induced by a Novel Food Supplement Based on Epilobium angustifolium, Ptychopetalum olacoides, Ginkgo biloba, and Equisetum arvense Extracts and Citrulline in the Lower Urinary Tract: Preclinical and Clinical Evidence

Phytotherapy Research, EarlyView.
ABSTRACT Oxyfil is a dietary supplement including plant extracts from Epilobium angustifolium, Ptychopetalum olacoides (Muira puama), Ginkgo biloba, and Equisetum arvense and citrulline. The aim of the study was to investigate the protective effects on prostatic muscles of the Oxyfil formulation in an in vitro experimental model consisting of isolated ...
Annalisa Chiavaroli, Alessandra Acquaviva, Simonetta Cristina Di Simone, Stefano Salvatore, Silvia Messina, Carolina Morgante, Chiara Lupi, Silvia Villa, Gokhan Zengin, Giustino Orlando, Luigi Menghini, Claudio Ferrante, Luigi Schips, Luca Cindolo, Michele Marchioni   +14 more
wiley   +1 more source

Both oral arginine and citrulline protect against eCM.

, 2019
Groups (n = 5) of mice were injected i.v. with PbA on day 0 PI and allowed to drink equimolar (731mM) arginine or citrulline ad libitum (~3ml/mouse).
Henri C. van der Heyde (6439625), Irene Gramaglia (6439613), Yu-Sun Chang (144676), Monique F. Stins (6439622), Wilson Caparros-Wanderley (6439619), Joyce Velez (6439616), Valery Combes (104149), Georges Grau (5206004)   +7 more
core   +1 more source

Mapping the tandem mass spectrometric characteristics of citrulline containing peptides [PDF]

, 2018
RATIONALE Protein citrullination (deimination) is a post-translational modification of proteins converting arginine(s) to citrulline(s). “Overcitrullination” could be associated with severe pathological conditions. Mass spectrometric analysis of modified
Gömöry, Ágnes, Drahos, László, Arnold Steckel, Lilla Turiák, Ferenc Hudecz, Steckel, Arnold, Uray, Katalin, Gitta Schlosser, Schlosser, Gitta (Vácziné), Katalin Uray, László Drahos, Turiák, Lilla, Hudecz, Ferenc, Ágnes Gömöry   +13 more
core   +1 more source

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir, Sanam Yousifie, Karl J. Jobst, André J. Simpson, Myrna J. Simpson   +4 more
wiley   +1 more source