Results 61 to 70 of about 34,606 (279)
Arthritis &Rheumatology, EarlyView.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou +10 more
wiley +1 more source
Protein hydrolysates in cell culture: Toward multi‐omics characterization
Biotechnology Progress, EarlyView.While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe +3 more
wiley +1 more source
Characterization of Monoclonal Antibodies Recognizing Citrulline-Modified Residues
Frontiers in Immunology, 2022 BackgroundCitrullination is a post-translational protein modification linked to the occurrence and development of a variety of diseases. The detection of citrullinated proteins is predominately based on antibody detection although currently available ...
Yaqiong Chen +9 more
doaj +1 more source
Was citrulline first a laxative substance? The truth about modern citrulline and its isolation [PDF]
, 2011 Citrulline is a non-protein amino acid and is produced by the enterocytes of the small bowel. The isolation though of citrulline is generally ascribed to the 1930s.
Fragkos, K, Forbess, A
core
Source and fate of circulating citrulline
, 1981 Previous work has demonstrated a continuous release of citrulline from the small intestine into the circulation. To evaluate the physiologic significance of this process, we have now measured citrulline uptake and release by isolated, perfused livers and,
H. G. Windmueller, A. E. Spaeth
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara +20 more
wiley +1 more source
Correlation of plasma metabolites with glucose and lipid fluxes in human insulin resistance
Obesity Science & Practice, 2020 Summary Objective Insulin resistance develops prior to the onset of overt type 2 diabetes, making its early detection vital. Direct accurate evaluation is currently only possible with complex examinations like the stable isotope‐based hyperinsulinemic ...
Annick V. Hartstra +10 more
doaj +1 more source
Endotoxemia affects citrulline, arginine and glutamine bioavailability
, 2011 International audienceBACKGROUND:Sepsis considerably alters the intestinal barrier functions, which in turn modify the absorption and bioavailability of nutrients.
Philippe Arnaud +16 more
core +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source