Results 31 to 40 of about 6,525 (164)
Biology Open, 2016 Polyamines are positively-charged organic molecules that are important for cellular growth and division. Polyamines and their synthesizing enzymes are particularly abundant in rapidly proliferating eukaryotic cells such as parasitic protozoa and cancer ...
Robert J. Hart +4 more
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Molecules, 2019 l-Ornithine decarboxylase (ODC) is the rate-limiting enzyme of de novo polyamine synthesis in humans and fungi. Elevated levels of polyamine by over-induction of ODC activity in response to tumor-promoting factors has been frequently reported.
Ashraf S.A. El-Sayed +9 more
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Frontiers in Cellular and Infection Microbiology, 2019 Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati +11 more
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Cell & Bioscience, 2022 Background Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application.
Ningning Liu +3 more
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Impact of nicotine pathway downregulation on polyamine biosynthesis and leaf ripening in tobacco
Plant Direct, 2021 Traditional breeding and molecular approaches have been used to develop tobacco varieties with reduced nicotine and secondary alkaloid levels. However, available low‐alkaloid tobacco varieties have impaired leaf quality likely due to the metabolic ...
Greta Nölke +12 more
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Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes. [PDF]
PLoS ONE, 2013 The intracellular levels of polyamines, polycations implicated in proliferation, differentiation and cell survival, are regulated by controlling their biosynthesis, catabolism and transport.
Carlos López-Garcia +5 more
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Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Medical Sciences, 2017 Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang +2 more
doaj +1 more source
Food Safety and Health, EarlyView.This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu +5 more
wiley +1 more source
Syntheses of ornithine decarboxylase inhibitors: D- and DL-.ALPHA.-hydrazinoornithine.
Chemical and Pharmaceutical Bulletin, 1976 The absolute configuration of optically active α-hydrazinoornithine which was prepared by the reaction of hydrazine with the α-bromo acid derived from L-ornithine was proved to be the D-configuration. In addition, racemic α-hydrazinoornithine was first prepared by two different methods.
SAWAYAMA, TADAHIRO +2 more
openaire +3 more sources