Results 31 to 40 of about 6,839 (201)
Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications
Medical Sciences, 2018 The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Bruno Ramos-Molina +2 more
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Glucocorticoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells
Neoplasia: An International Journal for Oncology Research, 2002 Glucocorticoids are well-known apoptotic agents in certain classes of lymphoid cell malignancies. Reduction of intracellular polyamine levels by use of inhibitors that block polyamine synthesis slows or inhibits growth of many cells in vitro.
Aaron L. Miller +4 more
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Frontiers in Oncology, 2021 Personized treatment of breast cancer is still a challenge, and more treatment options for breast cancer are warranted. Combination therapies have been a highly appreciated strategy for breast cancer treatment in recent years, and the development of new ...
Hongyan Ma +15 more
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Memorias do Instituto Oswaldo Cruz, 2005 The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide ...
Maria BR Acosta +3 more
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All Life, 2023 Colorectal cancer (CRC) is the third most common cancer in the world, with increasing morbidity and mortality. The current diagnosis and treatment plan rely on early detection and comprehensive treatment based on surgery.
Chengyang Chen, Xia Jiang, Zengren Zhao
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Biomolecules, 2022 Background: Alterations in the neural polyamine system are known to be associated with different brain pathological conditions. In addition, the regulation of enzymes involved in polyamine metabolism such as ornithine decarboxylase (ODC), antizymes (AZs),
Ana Lambertos +5 more
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Biology Open, 2016 Polyamines are positively-charged organic molecules that are important for cellular growth and division. Polyamines and their synthesizing enzymes are particularly abundant in rapidly proliferating eukaryotic cells such as parasitic protozoa and cancer ...
Robert J. Hart +4 more
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Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
, 2005 Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells from E mu-Myc transgenic mice. Here, we report that disabling one of these Myc
Nilsson, JA;Keller, UB;Baudino, TA;Yang, C;Norton, S;Old, JA;Nilsson, LM;Neale, G;Kramer, DL;Porter, CW;Cleveland, JL
core +3 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati +11 more
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Cell & Bioscience, 2022 Background Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application.
Ningning Liu +3 more
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