Results 51 to 60 of about 6,839 (201)
, 2020 Ornithine decarboxylase (ODC) plays an important role in various biological processes; however, its role in plant secondary metabolism, especially in the biosynthesis of tropane alkaloids (TAs) such as pharmaceutical hyoscyamine, anisodamine, and ...
Siqi Li (2283472) +8 more
core +1 more source
Cell Proliferation, EarlyView.Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang +9 more
wiley +1 more source
, 2015 Agmatine (4-aminobutylguanidine), a dicationic molecule at physiological pH, exerts relevant modulatory actions at many different molecular target sites in mammalian cells, having been suggested that the administration of this compound may have ...
López-Contreras, Andrés J. +7 more
core +1 more source
Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro [PDF]
, 1987 We quantitated the activity of ornithine decarboxylase (ODC) in homogenates and subcellular fractions of inner ear tissues from the rat and guinea pig and demonstrate inhibition of cochlear ODC by the aminoglycoside neomycin.
Gerhardt, Hans-J. +2 more
core +1 more source
Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers
Medical Sciences, 2017 Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro +2 more
doaj +1 more source
Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola
Insect Molecular Biology, EarlyView.Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez +1 more
wiley +1 more source
BioTechniques, 2007 High stabilities of reporter proteins and their messenger RNAs (mRNAs) interfere with the detection of rapid transient changes in gene expression, such as transcriptional blocks posed by genotoxic DNA lesions. We have modified a green fluorescent protein
Nataliya Kitsera +2 more
doaj +1 more source
The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases
Journal of Periodontal Research, EarlyView.This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley +1 more source
Attempted routes towards the synthesis of fluorinated analogues of ornithine as potential inhibitors of ornithine decarboxylase [PDF]
, 2007 Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2007.Human African Trypanosomiasis (HAT) is a disease that threatens more then 60 million men, woman and children in Africa.
De Villiers, Jandre
core
, 2011 Pyridoxal-5'-phosphate (vitamin B(6))-dependent enzymes play central roles in the metabolism of amino acids. Moreover, the synthesis of polyamines, which are essential for cell growth, and of biogenic amines, such as histamine and other signal ...
Christen, P +5 more
core +1 more source