Results 61 to 70 of about 645,023 (159)

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, EarlyView.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

Perturbation of Spermine Homoeostasis Uncouples Hypersensitive Cell Death From Systemic Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Polyamines are key regulators of plant stress responses, yet their contribution to coordinating local immune responses with systemic immunity remains poorly understood. Here, we investigated how spermine (Spm) homeostasis influences local and systemic defence responses in Arabidopsis thaliana following inoculation with Pseudomonas syringae pv.
Jiaqi Zhao, Kostadin E. Atanasov, Olga Jauregui, Rubén Alcázar   +3 more
wiley   +1 more source

The Microbiome in Glioblastoma: Mechanisms, Tumor–Immune Interactions, and Translational Perspectives

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Proposed microbiome‐related pathways and translational landscape in glioblastoma. Gut dysbiosis may alter microbial metabolites, inflammatory mediators, barrier integrity, immune signaling, and vagal communication, thereby influencing the GBM neuroimmune microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi‐S, Priya Priyadarshini‐Nayak, Anima Nanda, Shaker Al‐Hasnaawei, Akanksha Bhatt, Ashish Singh‐Chauhan, Siya Singla, Manoj Kumar Mishra   +8 more
wiley   +1 more source

Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer.

PLoS ONE, 2019
Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine synthesis. The two ODC antizyme inhibitors (AZIN1) and (AZIN2) are regulators of the catalytic activity of ODC.
Tuomas Kaprio, Tiina Rasila, Jaana Hagström, Harri Mustonen, Petri Lankila, Caj Haglund, Leif C Andersson   +6 more
doaj   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin

, 1987
Treatment of 29-day-old female Sprague-Dawley rats with human chorionic gonadotrophin (hCG) produced a large and rapid increase in the activity of ornithine decarboxylase.
A. E. Pegg, G. J. Sertich, L. Persson
core   +1 more source

Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACTThe effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength and wire‐grip tests.
Yingjia Zhou, Shaoli Zhao, Hongmei Shen, Jia Wu, Mei Li, Shan Liu, Jian Yang, Xiaowei Jin, Fan Li, Huantian Cui   +9 more
wiley   +1 more source

Phosphorylation of ornithine decarboxylase in intact erythroleukemia cells

, 1990
32P-labeled ornithine decarboxylase was isolated by immunoprecipitation from murine erythroleukemia cells incubated in a medium containing [32P]ortophosphoric acid.
Meggio F., Marmiroli S., Guarnieri C., Flamigni F., Pinna L. A.   +4 more
core   +1 more source

Antizyme inhibitor family: biological and translational research implications

Cell Communication and Signaling
Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine ...
Qiaohui Feng, Huijie Wang, Youcheng Shao, Xiaoyan Xu   +3 more
doaj   +1 more source

Polyamine Metabolism for Drug Intervention in Trypanosomatids

Pathogens
Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world’s poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease and different types of
Yolanda Pérez-Pertejo, Carlos García-Estrada, María Martínez-Valladares, Sankaranarayanan Murugesan, Rosa M. Reguera, Rafael Balaña-Fouce   +5 more
doaj   +1 more source