Results 81 to 90 of about 6,839 (201)

Transcriptomic analysis reveals the hepatic response mechanisms of the Chinese spiny frog (Quasipaa spinosa) to Citrobacter freundii infection

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract To elucidate the pathogen and host response mechanisms underlying mass mortality in Quasipaa spinosa, dominant bacteria were isolated from diseased individuals and identified as Citrobacter freundii by morphological, physiological, and biochemical characterization, 16S rRNA sequencing, and phylogenetic analysis.
Yanhong Li, Baohong Zhou, Yiran Lu, Yi Zang, Minghao Hu, Qiaochen Jin, Wenbin Fang, Shanjian Zheng   +7 more
wiley   +1 more source

Polyamine Metabolism for Drug Intervention in Trypanosomatids

Pathogens
Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world’s poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease and different types of
Yolanda Pérez-Pertejo, Carlos García-Estrada, María Martínez-Valladares, Sankaranarayanan Murugesan, Rosa M. Reguera, Rafael Balaña-Fouce   +5 more
doaj   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3597-3615, June 2026.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

Antizyme inhibitor family: biological and translational research implications

Cell Communication and Signaling
Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine ...
Qiaohui Feng, Huijie Wang, Youcheng Shao, Xiaoyan Xu   +3 more
doaj   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Potentiation by Retinoic Acid of Ornithine Decarboxylase Induction by Phytohemagglutinin or Phorbol 12-Myristate 13-Acetate in Guinea Pig Lymphocytes

, 1986
Retinoic acid potentiated the increases in ornithine decarboxylase (L-ornithine carboxy-lyase [EC 4.1.1.17]) activity, [3H]difluoromethylornithine binding to ornithine decarboxylase, intracellular levels of polyamines and DNA synthesis in guinea pig ...
Seiji Morisawa, Isao Matsui-yuasa, Yasuko Mimura, Shuzo Otani   +3 more
core  

Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation

Nature Communications
Metabolic syndrome increases the risk of endometrial cancer development and progression, but the mechanism remains unclear. We find that polyamine metabolites are notably elevated in the sera and tumor tissues of endometrial cancer patients with ...
Lirong Zhai, Yuan Cheng, Meixuan Wu, Tianzhuo Wang, Meichen Yin, Xiao Yang, Bowen Sun, Chengcheng Li, Miao He, Yi Sun, Yiqian Zhao, Yuqi Xing, Bo Liu, Ling Zhou, Yuanyuan Liu, Miao Yu, Yijiao He, Hongquan Zhang, Jun Zhan, Jianliu Wang   +19 more
doaj   +1 more source

New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility.

PLoS ONE, 2018
The specific role of polyamines in the testis physiology is not fully understood. Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake.
Ana Lambertos, Bruno Ramos-Molina, Andrés J López-Contreras, Asunción Cremades, Rafael Peñafiel   +4 more
doaj   +1 more source

Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation

, 2009
Creating transition-state mimics has proven to be a powerful strategy in developing inhibitors to treat malignant diseases in several cases. In the present study, structurally diverse coenzyme-substrate derivatives mimicking this type for pyridoxal 5 ...
Gehring, H, Heinz Gehring, Wu, F, Fang Wu   +3 more
core   +1 more source

Induction of ornithine decarboxylase in T/C-28a2 chondrocytes by lysophosphatidic acid: Signaling pathway and inhibition of cell proliferation

, 2005
Among several extracellular messengers tested, lysophosphatidic acid (LPA) was able to cause the most marked induction of ornithine decarboxylase (ODC) in serum-starved human T/C-28a2 chondrocytes.
Facchini, Annalisa, Flamigni, Flavio, Borzì, Rosa Maria   +2 more
core   +2 more sources