Results 91 to 100 of about 6,839 (201)

Regulation of ornithine decarboxylase activity in LoVo cells

, 1990
The role of Na+ and Na(+)-H+ exchange in the stimulation of ornithine decarboxylase (ODC) activity has been investigated in a human colon adenocarcinoma cell line, LoVo. Asparagine (Asn; 10 mM) or 10% fetal bovine serum (FBS) increased ODC activity from
S. A. McCormack, E. J. Gragoe, L. R. Johnson, L. L. Tague   +3 more
core   +1 more source

Independent Induction and Inhibition of Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities in Rat Epidermis

, 1982
Changes in the activities of ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) were investigated in rat epidermis after wounding the skin and application of 7,12-dimethylbenz(a)anthracene (DMBA), 2,3,7,8-tetrachlorodibenzo-p-dioxin ...
Raunio, Hannu, Pelkonen, Olavi
core   +1 more source

Characterization of alpha-difluoromethylornithine resistant Leishmania donovaniand its susceptibility to other inhibitors of the polyamine biosynthetic pathway

, 1996
The promastigote form ofLeishmania donovaniis sensitive to growth inhibition by DL -α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, exhibiting an IC50of 125µM.
Madhubala, R., Kapoor, Preeti, Mukhopadhyay, Rita   +2 more
core   +1 more source

Factors affecting the interconversion of ornithine decarboxylase forms in Physarum polycephalum

, 1979
The conversion between the two forms of ornithine decarboxylase (ODC) has been shown to occur rapidly and reversibly in Physarum polycephalum with slight changes in the osmolality of the organism\u27s growth media.
Kottas, G. Elizabeth
core  

α-Allenyl putrescine, an enzyme-activated irreversible inhibitor of bacterial and mammalian ornithine decarboxylases

, 1984
α-Allenyl putrescine (5,6-heptadiene-l,4-diamine) was designed as a new potential enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC). This compound, and more specifically its (R)-enantiomer, produced time-dependent inhibitions of E.
Danzin, Charles, Casara, Patrick, Charles Danzin, Patrick Casara   +3 more
core   +1 more source

Transforming growth factor β1 selectively regulates ornithine decarboxylase gene expression in malignant H‐ras transformed fibrosarcoma cell lines

Negative growth regulators such as the transforming growth factor beta (TGF-beta) family appear to be important inhibitors in most tissue types.

core   +1 more source

Inhibitors of Polyamine Biosynthetic Enzymes

, 2011
Inhibition of polyamine biosynthesis is now established as a useful therapeutic strategy for the treatment of a number of diseases. These include chemoprevention of cancer, treatment of African sleeping sickness, caused by Trypanosoma brucei gambiense ...
Anthony E. Pegg
core   +1 more source

Structure of mammalian ornithine decarboxylase at 1.6 Å resolution: stereochemical implications of PLP-dependent amino acid decarboxylases

, 1999
Background: Pyridoxal-5′-phosphate (PLP) dependent enzymes catalyze a broad range of reactions, resulting in bond cleavage at Cα, Cβ, or Cγ carbons of D and L amino acid substrates.
Hackert, Marvin L, Oliveira, Marcos A, Coffino, Philip, Kern, Andrew D   +3 more
core   +1 more source

Regulation of mammalian S-adenosylmethionine decarboxylase

, 1988
S-Adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines that is the rate limiting step in the formation of spermidine and spermine.
Pajunen, Antti, Shirahata, Akira, Kameji, Takaaki, Stanley, Bruce, Madhubala, Rentala, Pegg, Anthony E.   +5 more
core   +1 more source

Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells

, 1996
The polyamines are a family of low-molecular-weight organic cations that play essential intracellular regulatory roles in cell growth and differentiation. Elevations in cellular polyamine contents necessary for most physiological and pathological events
M. N. Gillespie, K. S. Harrod, J. W. Olson   +2 more
core   +1 more source