Results 41 to 50 of about 21,338 (219)

Multi-Temperature Crystallography of Polyamine Biosynthesis Enzymes Reveals Differing Active Site Conformations at RT than 100K [PDF]

Structural Dynamics
The polyamine biosynthetic pathway synthesizes the polyamines putrescine, spermidine, and spermine from ornithine and S-adenosyl methionine. These polyamines are important molecules in metabolism and are associated with growth and proliferation of cells ...
Jonathan A Clinger
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Determinants of the differential antizyme-binding affinity of ornithine decarboxylase. [PDF]

PLoS ONE, 2011
Ornithine decarboxylase (ODC) is a ubiquitous enzyme that is conserved in all species from bacteria to humans. Mammalian ODC is degraded by the proteasome in a ubiquitin-independent manner by direct binding to the antizyme (AZ).
Yen-Chin Liu, Den-Hua Hsu, Chi-Liang Huang, Yi-Liang Liu, Guang-Yaw Liu, Hui-Chih Hung   +5 more
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Melatonin treatment induces chilling tolerance by regulating the contents of polyamine, γ-aminobutyric acid, and proline in cucumber fruit

Journal of Integrative Agriculture, 2021
The mechanism of melatonin (MT) induced chilling tolerance in harvested cucumber fruit was investigated at commercial maturity. In this study, cucumber fruits were treated with 100 µmol L–1 MT at 4°C and 90% relative humidity for 15 d of storage.
Miilion P MADEBO, Si-ming LUO, Li WANG, Yong-hua ZHENG, Peng JIN   +4 more
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Putrescine Biosynthesis Inhibition in Tomato by DFMA and DFMO Treatment

Bio-Protocol, 2016
This protocol can be used to inhibit the biosynthesis of polyamines, specifically putrescine, in tomato plants grown with NH4+ as a solely N source. In general, polyamines are positively charged small metabolites implicated in physiological processes ...
Emma Fernández-Crespo, Ana González-Hernández, Loredana Scalschi, Eugenio Llorens, Pilar García-Agustín, Gemma Camañes   +5 more
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Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities

Bio-Protocol, 2014
The polyamines, spermidine (Spd) and spermine, and their diamine precursor putrescine, are important regulators of various cellular functions, such as proliferation and differentiation.
Mervi Hyvönen, Tuomo Keinänen, Leena Alhonen   +2 more
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Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme. [PDF]

PLoS Neglected Tropical Diseases, 2008
BACKGROUND: The polyamines putrescine, spermidine, and spermine are organic cations that are required for cell growth and differentiation. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is a ...
Anupam Jhingran, Prasad K Padmanabhan, Sushma Singh, Krishanpal Anamika, Abhijeet A Bakre, Sudha Bhattacharya, Alok Bhattacharya, Narayanaswamy Srinivasan, Rentala Madhubala   +8 more
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Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
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Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

, 2015
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis.
R. Jürgen Dohmen, Daniela Gödderz, R. Roshini Beenukumar, R. Palanimurugan   +3 more
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Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. [PDF]

PLoS ONE, 2013
Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc.
Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala, Shailly Tomar   +4 more
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Extended-Spectrum β-lactamase (ESBL) producing Enterobacter aerogenes phenotypically misidentified as Klebsiella pneumoniae or K. terrigena

BMC Microbiology, 2004
Background Enterobacter aerogenes and Klebsiella pneumoniae are common isolates in clinical microbiology and important as producers of extended spectrum β-lactamases (ESBL). The discrimination between both species, which is routinely based on biochemical
Verschraegen Gerda, Vandecandelaere Patricia, Wauters Georges, De Baere Thierry, Claeys Geert, Muylaert An, Vaneechoutte Mario   +6 more
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