Results 21 to 30 of about 21,397 (220)

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome [PDF]

, 2015
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis.
R. Jürgen Dohmen, Daniela Gödderz, R. Roshini Beenukumar, R. Palanimurugan   +3 more
core   +1 more source

Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus. [PDF]

PLoS ONE, 2013
The opportunistic fungal pathogen Aspergillus fumigatus produces siderophores for uptake and storage of iron, which is essential for its virulence. The main precursor of siderophore biosynthesis (SB), ornithine, can be produced from glutamate in the ...
Nicola Beckmann, Lukas Schafferer, Markus Schrettl, Ulrike Binder, Heribert Talasz, Herbert Lindner, Hubertus Haas   +6 more
doaj   +1 more source

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei [PDF]

, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Burgess, K., Burchmore, Richard J S, Barrett, M.P., Creek, D.J., Vincent, I.M., Woods, Debra, Karl Burgess, Richard J S Burchmore, Woods, Debra J, Creek, Darren, Debra J. Woods (167740), Creek, Darren John, Isabel M Vincent, Vincent, Isabel M, Michael P Barrett, Darren J. Creek (167726), Woods, D.J., Isabel M. Vincent (167717), Woods Debra J., Burgess Karl, Burgess, Karl, Burchmore, Richard, Barrett, Michael P, Vincent, Isabel, Barrett Michael P., Burchmore, R.J.S., Creek Darren J., Richard J. S. Burchmore (167742), Vincent Isabel M., Darren J Creek, Karl Burgess (167732), Debra J Woods, Barrett, Michael, Michael P. Barrett (167748), Burchmore Richard J. S.   +34 more
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Mitogen‐Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation–Induced Cardiac Hypertrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe transient receptor potential vanilloid type 1 (TRPV1) is expressed in the cardiovascular system, and increased TRPV1 expression has been associated with cardiac hypertrophy.
Mai Chen, Jiajia Xin, Baohui Liu, Liyang Luo, Jiayi Li, Wen Yin, Mingkai Li   +6 more
doaj   +1 more source

Sensing and adaptation to low pH mediated by inducible amino acid decarboxylases in Salmonella. [PDF]

PLoS ONE, 2011
During the course of infection, Salmonella enterica serovar Typhimurium must successively survive the harsh acid stress of the stomach and multiply into a mild acidic compartment within macrophages.
Julie P M Viala, Stéphane Méresse, Bérengère Pocachard, Aude-Agnès Guilhon, Laurent Aussel, Frédéric Barras   +5 more
doaj   +1 more source

Leishmania donovani: cellular control of ornithine decarboxylase in promastigotes [PDF]

, 1995
Ornithine decarboxylase, a key enzyme in polyamine biosynthesis, is essential for normal cell growth and proliferation. Furthermore, the inhibition of this enzyme is a potential way of controlling such growth.
Madhubala, R., Mukhopadhyay, Rita
core   +1 more source

Species of Staphylococcus and Bacillus isolated from traditional sausages as producers of biogenic amines.

Frontiers in Microbiology, 2012
Histidine, lysine, ornithine and tyrosine decarboxylase activities were tested in 38 strains of Staphylococcus (15 of Staph. equorum, 11 of Staph. epidermidis, 7 of Staph. saprophyticus, and 5 of Staph.
Roberto eBermúdez, Jose M. Lorenzo, Sonia eFonseca, Inmaculada eFranco, Javier eCarballo   +4 more
doaj   +1 more source

mRNA dynamics and alternative conformations adopted under low and high arginine concentrations control polyamine biosynthesis in Salmonella. [PDF]

PLoS Genetics, 2019
Putrescine belongs to the large group of polyamines, an essential class of metabolites that exists throughout all kingdoms of life. The Salmonella speF gene encodes an inducible ornithine decarboxylase that produces putrescine from ornithine.
Tamar Ben-Zvi, Alina Pushkarev, Hemda Seri, Maya Elgrably-Weiss, Kai Papenfort, Shoshy Altuvia   +5 more
doaj   +1 more source

Uric Acid Deteriorates Load-Free Cell Shortening of Cultured Adult Rat Ventricular Cardiomyocytes via Stimulation of Arginine Turnover

Biology, 2022
Hyperuricemia is a risk factor for heart disease. Cardiomyocytes produce uric acid via xanthine oxidase. The enzymatic reaction leads to oxidative stress in uric-acid-producing cells.
Martin Weber, Rolf Schreckenberg, Klaus-Dieter Schlüter   +2 more
doaj   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek Darren, Watson David G., Burchmore, Richard J S, Barrett, M.P., Michael P. Barrett, Woods, DJ, Pui Ee Wong, Vincent, I.M., Darren Creek, Vincent, IM, Kamleh, M.A., Richard J S Burchmore, Wong, P.E., Kamleh, Mohammed A, Woods, Debra J, Creek, Darren, Richard J. S. Burchmore, Wong, PE, Vincent, Isabel M, Isabel M Vincent, Michael P Barrett, Isabel M. Vincent, Kamleh, MA, Watson, DG, Woods, D.J., Wong, Pui Ee, Woods Debra J., Mohammed A. Kamleh, David G. Watson, Barrett, Michael P, Creek, D., Barrett Michael P., Barrett, MP, Burchmore, R.J.S., Wong Pui Ee, David G Watson, Kamleh Mohammed A., Vincent Isabel M., Watson, David G, Burchmore, RJS, Creek, D, Watson, D.G., Debra J Woods, Debra J. Woods, Mohammed A Kamleh, Burchmore Richard J. S.   +45 more
core   +1 more source