Results 21 to 30 of about 50,539 (212)

Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus. [PDF]

PLoS ONE, 2013
The opportunistic fungal pathogen Aspergillus fumigatus produces siderophores for uptake and storage of iron, which is essential for its virulence. The main precursor of siderophore biosynthesis (SB), ornithine, can be produced from glutamate in the ...
Nicola Beckmann, Lukas Schafferer, Markus Schrettl, Ulrike Binder, Heribert Talasz, Herbert Lindner, Hubertus Haas   +6 more
doaj   +1 more source

Regulation of Ornithine Decarboxylase [PDF]

Journal of Biological Chemistry, 2006
Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to
openaire   +2 more sources

Sensing and adaptation to low pH mediated by inducible amino acid decarboxylases in Salmonella. [PDF]

PLoS ONE, 2011
During the course of infection, Salmonella enterica serovar Typhimurium must successively survive the harsh acid stress of the stomach and multiply into a mild acidic compartment within macrophages.
Julie P M Viala, Stéphane Méresse, Bérengère Pocachard, Aude-Agnès Guilhon, Laurent Aussel, Frédéric Barras   +5 more
doaj   +1 more source

Mitogen‐Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation–Induced Cardiac Hypertrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe transient receptor potential vanilloid type 1 (TRPV1) is expressed in the cardiovascular system, and increased TRPV1 expression has been associated with cardiac hypertrophy.
Mai Chen, Jiajia Xin, Baohui Liu, Liyang Luo, Jiayi Li, Wen Yin, Mingkai Li   +6 more
doaj   +1 more source

mRNA dynamics and alternative conformations adopted under low and high arginine concentrations control polyamine biosynthesis in Salmonella. [PDF]

PLoS Genetics, 2019
Putrescine belongs to the large group of polyamines, an essential class of metabolites that exists throughout all kingdoms of life. The Salmonella speF gene encodes an inducible ornithine decarboxylase that produces putrescine from ornithine.
Tamar Ben-Zvi, Alina Pushkarev, Hemda Seri, Maya Elgrably-Weiss, Kai Papenfort, Shoshy Altuvia   +5 more
doaj   +1 more source

Species of Staphylococcus and Bacillus isolated from traditional sausages as producers of biogenic amines.

Frontiers in Microbiology, 2012
Histidine, lysine, ornithine and tyrosine decarboxylase activities were tested in 38 strains of Staphylococcus (15 of Staph. equorum, 11 of Staph. epidermidis, 7 of Staph. saprophyticus, and 5 of Staph.
Roberto eBermúdez, Jose M. Lorenzo, Sonia eFonseca, Inmaculada eFranco, Javier eCarballo   +4 more
doaj   +1 more source

Ornithine Decarboxylase in Skin

Journal of Investigative Dermatology, 1980
Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
openaire   +2 more sources

Uric Acid Deteriorates Load-Free Cell Shortening of Cultured Adult Rat Ventricular Cardiomyocytes via Stimulation of Arginine Turnover

Biology, 2022
Hyperuricemia is a risk factor for heart disease. Cardiomyocytes produce uric acid via xanthine oxidase. The enzymatic reaction leads to oxidative stress in uric-acid-producing cells.
Martin Weber, Rolf Schreckenberg, Klaus-Dieter Schlüter   +2 more
doaj   +1 more source

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei [PDF]

, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Burgess, K., Burchmore, Richard J S, Barrett, M.P., Creek, D.J., Vincent, I.M., Woods, Debra, Karl Burgess, Richard J S Burchmore, Woods, Debra J, Creek, Darren, Debra J. Woods (167740), Creek, Darren John, Isabel M Vincent, Vincent, Isabel M, Michael P Barrett, Darren J. Creek (167726), Woods, D.J., Isabel M. Vincent (167717), Woods Debra J., Burgess Karl, Burgess, Karl, Burchmore, Richard, Barrett, Michael P, Vincent, Isabel, Barrett Michael P., Burchmore, R.J.S., Creek Darren J., Richard J. S. Burchmore (167742), Vincent Isabel M., Darren J Creek, Karl Burgess (167732), Debra J Woods, Barrett, Michael, Michael P. Barrett (167748), Burchmore Richard J. S.   +34 more
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Multi-Temperature Crystallography of Polyamine Biosynthesis Enzymes Reveals Differing Active Site Conformations at RT than 100K [PDF]

Structural Dynamics
The polyamine biosynthetic pathway synthesizes the polyamines putrescine, spermidine, and spermine from ornithine and S-adenosyl methionine. These polyamines are important molecules in metabolism and are associated with growth and proliferation of cells ...
Jonathan A Clinger
doaj   +1 more source