Results 11 to 20 of about 50,539 (212)

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

npj Precision Oncology, 2017
Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He, Eunmiri Roh, Ke Yao, Kangdong Liu, Xing Meng, Fangfang Liu, Penglei Wang, Ann M. Bode, Zigang Dong   +8 more
doaj   +2 more sources

Structural and metabolic studies on normal and pathological bone [PDF]

, 1985
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Bone is refractory to most conventional biochemical Procedures. However because it is now possible to cut sections (e. g.
Dodds, Robert A
core   +7 more sources

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation-Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis. [PDF]

Cell Prolif
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Zhang M, Chang F, Ge S, Cao F, Fu P, Zhang H, Chen M, Li Y, Tang P, Yin P.   +9 more
europepmc   +2 more sources

A safety catch for ornithine decarboxylase degradation

Microbial Cell, 2015
Christof Taxis
doaj   +2 more sources

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek Darren, Watson David G., Burchmore, Richard J S, Barrett, M.P., Michael P. Barrett, Woods, DJ, Pui Ee Wong, Vincent, I.M., Darren Creek, Vincent, IM, Kamleh, M.A., Richard J S Burchmore, Wong, P.E., Kamleh, Mohammed A, Woods, Debra J, Creek, Darren, Richard J. S. Burchmore, Wong, PE, Vincent, Isabel M, Isabel M Vincent, Michael P Barrett, Isabel M. Vincent, Kamleh, MA, Watson, DG, Woods, D.J., Wong, Pui Ee, Woods Debra J., Mohammed A. Kamleh, David G. Watson, Barrett, Michael P, Creek, D., Barrett Michael P., Barrett, MP, Burchmore, R.J.S., Wong Pui Ee, David G Watson, Kamleh Mohammed A., Vincent Isabel M., Watson, David G, Burchmore, RJS, Creek, D, Watson, D.G., Debra J Woods, Debra J. Woods, Mohammed A Kamleh, Burchmore Richard J. S.   +45 more
core   +5 more sources

The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases

Frontiers in Plant Science, 2020
Arginine acts as a precursor of polyamines in plants in two known pathways, agmatine and ornithine routes. It is decarboxylated to agmatine by arginine decarboxylase, and then transformed to putrescine by the consecutive action of agmatine iminohydrolase
Bartosz Sekula
doaj   +1 more source

Characterization and Mechanism of Tea Polyphenols Inhibiting Biogenic Amine Accumulation in Marinated Spanish Mackerel

Foods, 2023
Putrescine is a low-molecular-weight organic compound that is widely found in pickled foods. Although the intake of biogenic amines is beneficial to humans, an excessive intake can cause discomfort.
Zhe Xu, Jiale Chang, Jiamin Zhou, Yixin Shi, Hui Chen, Lingyu Han, Maolin Tu, Tingting Li   +7 more
doaj   +1 more source

Immunocytochemical Detection of Ornithine Decarboxylase [PDF]

Journal of Histochemistry & Cytochemistry, 1999
Ornithine decarboxylase (ODC), a regulatory enzyme of polyamine biosynthesis, is involved in cell growth and differentiation. Lack of information about the exact cellular and subcellular localization of ODC is one of the main obstacles to precise interpretation of the biological roles of the ODC/polyamine system.
Schipper, R.G., Romain, N., Otten, A.A.C., Tan, J.B., Lange, W.P.H., Verhofstad, A.A.J.   +5 more
openaire   +3 more sources

Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer

Endocrine Connections, 2017
In this study, it was aimed to investigate the relationship between diabetes and breast cancer and the detection of enzymes and ornithine levels in polyamine synthesis pathway in diabetes, breast cancer and diabetic breast cancer patients.
V Kenan Çelik, Sercan Kapancık,, Turgut Kaçan, Selen Baloglu Kaçan, Serkan Kapancık, Hasan Kılıçgün   +5 more
doaj   +1 more source

Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Frontiers in Pharmacology, 2020
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras, Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal, Andrés Rivera-Dictter, Antonia Martin-Martin, Rafael A. Burgos, Pablo Alarcon, Rodrigo López-Muñoz   +9 more
doaj   +1 more source