Spectrophotometric assay for ornithine decarboxylase [PDF]
Analytical Biochemistry, 1987 A rapid and sensitive spectrophotometric assay for ornithine decarboxylase is described. It is based on the observation that the product of ornithine decarboxylase, putrescine, reacts with 2,4,6-trinitrobenzenesulfonic acid to give a colored product soluble in 1-pentanol whereas ornithine does not.
Rowland H Davis +2 more
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Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
doaj +2 more sources
DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park +2 more
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Metabolic Characterization of Hyoscyamus niger Ornithine Decarboxylase [PDF]
Frontiers in Plant Science, 2019 Ornithine decarboxylase (ODC) catalyzes ornithine decarboxylation to yield putrescine, a key precursor of polyamines, and tropane alkaloids (TAs). Here, to investigate in depth the role of ODC in polyamine/TA biosynthesis and to provide a candidate gene ...
Tengfei Zhao +9 more
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Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase. [PDF]
PLoS ONE, 2019 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system that includes antizymes (AZs ...
Ana Lambertos, Rafael Peñafiel
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Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum [PDF]
Microbiology Spectrum, 2022 Putrescine (Put) has been shown to play an important regulatory role in cell growth in organisms. As the primary center regulating the homeostasis of polyamine (PA) content, ornithine decarboxylase antizyme (AZ) can regulate PA content through feedback ...
Tao Wu +12 more
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Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
npj Precision Oncology, 2017 Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He +8 more
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Ornithine Decarboxylase in Skin
Journal of Investigative Dermatology, 1980 Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
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Ornithine decarboxylase as a therapeutic target for endometrial cancer. [PDF]
PLoS ONE, 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and
Hong Im Kim +9 more
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Ornithine Decarboxylase in Rat Skin
Journal of Investigative Dermatology, 1978 Ornithine decarboxylase (ODC; E.C.4.1.1.17) activities can be stimulated 2-10 fold in rat epidermis and dermis by hair plucking. Stimulation does not involve the removal of a soluble ODC inhibitor. ODC activity in the dermis and whole skin decreased with aging, while the epidermis showed little change.
Morrison, Deane M., Goldsmith, Lowell A.
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