Results 11 to 20 of about 21,397 (220)
Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression [PDF]
npj Precision Oncology, 2017 Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He +8 more
doaj +2 more sources
Ornithine Decarboxylase in Skin [PDF]
Journal of Investigative Dermatology, 1980 Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
openaire +3 more sources
Ornithine Decarboxylase in Rat Skin [PDF]
Journal of Investigative Dermatology, 1978 Ornithine decarboxylase (ODC; E.C.4.1.1.17) activities can be stimulated 2-10 fold in rat epidermis and dermis by hair plucking. Stimulation does not involve the removal of a soluble ODC inhibitor. ODC activity in the dermis and whole skin decreased with aging, while the epidermis showed little change.
Morrison, Deane M., Goldsmith, Lowell A.
openaire +3 more sources
A safety catch for ornithine decarboxylase degradation [PDF]
Microbial Cell, 2015 Christof Taxis
doaj +2 more sources
The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases
Frontiers in Plant Science, 2020 Arginine acts as a precursor of polyamines in plants in two known pathways, agmatine and ornithine routes. It is decarboxylated to agmatine by arginine decarboxylase, and then transformed to putrescine by the consecutive action of agmatine iminohydrolase
Bartosz Sekula
doaj +1 more source
Foods, 2023 Putrescine is a low-molecular-weight organic compound that is widely found in pickled foods. Although the intake of biogenic amines is beneficial to humans, an excessive intake can cause discomfort.
Zhe Xu +7 more
doaj +1 more source
Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer
Endocrine Connections, 2017 In this study, it was aimed to investigate the relationship between diabetes and breast cancer and the detection of enzymes and ornithine levels in polyamine synthesis pathway in diabetes, breast cancer and diabetic breast cancer patients.
V Kenan Çelik +5 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras +9 more
doaj +1 more source
Regulation of Ornithine Decarboxylase [PDF]
Journal of Biological Chemistry, 2006 Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to
openaire +2 more sources
Immunocytochemical Detection of Ornithine Decarboxylase [PDF]
Journal of Histochemistry & Cytochemistry, 1999 Ornithine decarboxylase (ODC), a regulatory enzyme of polyamine biosynthesis, is involved in cell growth and differentiation. Lack of information about the exact cellular and subcellular localization of ODC is one of the main obstacles to precise interpretation of the biological roles of the ODC/polyamine system.
Schipper, R.G. +5 more
openaire +3 more sources