Results 11 to 20 of about 3,690 (206)

EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]

Adv Sci (Weinh)
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Li Y, Hu X, Yang C, Liu N, Wang L, Cai X, Tang M, Cao Y, Shang L, Shi F.   +9 more
europepmc   +2 more sources

DFMO Carbon Dots for Treatment of Neuroblastoma and Bioimaging

ACS Applied Bio Materials, 2022
Neuroblastoma (NB) is a pediatric malignancy affecting the peripheral nervous system. Despite recent advancements in treatment, many children affected with NB continue to submit to this illness, and new therapeutic strategies are desperately needed.
Yiqun Zhou, Paudyal, Suraj, Jun Gu, Leblanc, Roger M., Pressman, Yelena, Yelena Pressman, Vanni, Steven, Frederic Anthony Vallejo, Vallejo, Frederic Anthony, Zhou, Yiqun, Roger M. Leblanc, Suraj Paudyal, Gu, Jun, Mintz, Keenan J., Regina M. Graham, Emel Kirbas Cilingir, Cilingir, Emel Kirbas, Keenan J. Mintz, Steven Vanni, Graham, Regina M.   +19 more
core   +3 more sources

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation-Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis. [PDF]

Cell Prolif
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Zhang M, Chang F, Ge S, Cao F, Fu P, Zhang H, Chen M, Li Y, Tang P, Yin P.   +9 more
europepmc   +2 more sources

Difluoromethylornithine modulates mutant K-RAS signaling pathways in pancreatic cancer cells [PDF]

Amino Acids
Oncogenic mutations in the K-RAS small GTPase occur in more than 90% of human PDACs and cause dysregulation of multiple metabolic pathways, including polyamine metabolism.
Hwudaurw Chen, David E. Stringer, Haiyan Cui, Eugene W. Gerner, Natalia A. Ignatenko   +4 more
doaj   +2 more sources

Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO. [PDF]

PLoS ONE, 2020
BackgroundAnti-GD2 therapy with dinutuximab is effective in improving the survival of high-risk neuroblastoma patients in remission and after relapse. However, allodynia is the major dose-limiting side effect, hindering its use for neuroblastoma patients
Mitchell B Diccianni, Katarzyna Kempińska, Jon A Gangoti, Alice L Yu, Linda S Sorkin   +4 more
doaj   +2 more sources

DFMO inhibition of neuroblastoma tumorigenesis

Cancer Medicine
Background Most high‐risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event‐free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during ...
Divya Gandra, David H. Mulama, David M. Foureau, Kimberly Q. McKinney, Elizabeth Kim, Kaitlyn Smith, Jason Haw, Abhinav Nagulapally, Giselle L. Saulnier Sholler   +8 more
doaj   +3 more sources

Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy.
Yan Lin, Xiaojie Zhang, Wei Xiao, Bo Li, Jun Wang, Li Jin, Jie Lian, Li Zhou, Jicheng Liu   +8 more
doaj   +2 more sources

Efferocytosis-Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer. [PDF]

Adv Sci (Weinh)
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Li W, Ying F, Pang X, Wu Q, Li G, Huang L, Xin J, Liu X, Liu P, Xu X, Tan S, Gao Y, Liu T, Sun S, Wang X, Wen Y, Cai L, Du S, Zhang Y, Cai J.   +19 more
europepmc   +2 more sources

Functional Characterization of the P‐Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters [PDF]

FASEB J
ATP13A3 and ATP13A4 mediate the plasma membrane uptake of the polyamines, putrescine and spermidine, in an ATP‐dependent manner. ATP13A3 is broadly expressed across human tissues, whereas ATP13A4 is expressed at relatively high levels in the brain and lung.
Morimoto H, Yasujima T, Yamasaki M, Yamashiro T, Yuasa H.   +4 more
europepmc   +2 more sources

New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on Trypanosoma cruzi in vitro and in vivo [PDF]

Frontiers in Cellular and Infection Microbiology
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is currently a global health problem. Its multiple forms of transmission, which favor the spread of the infection, and the limited treatment options—still restricted to only two drugs ...
Santiago José Martínez, Santiago José Martínez, María Cristina Vanrell, María Cristina Vanrell, Xiaomo Li, Carolina Carrillo, David M. Engman, Patricia Silvia Romano, Patricia Silvia Romano   +8 more
doaj   +2 more sources