Results 1 to 10 of about 49 (49)
Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
Biomedicines, 2023 GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander +3 more
doaj +1 more source
Biomolecules, 2021 Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen +4 more
doaj +1 more source
Frontiers in Chemistry, 2021 Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2.
Joanna Bojarska +8 more
doaj +1 more source
DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park +2 more
doaj +1 more source
Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation
Animal Nutrition, 2020 l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal epithelial cells.
Jing Wang +5 more
doaj +1 more source
Biomolecules, 2020 We report the results of our in silico study of approved drugs as potential treatments for COVID-19. The study is based on the analysis of normal modes of proteins.
Ognjen Perišić
doaj +1 more source
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells
Medical Sciences, 2022 Ovarian cancer accounts for 3% of the total cancers in women, yet it is the fifth leading cause of cancer deaths among women. The BRCA1/2 germline and somatic mutations confer a deficiency of the homologous recombination (HR) repair pathway.
Olivia El Naggar +3 more
doaj +1 more source
A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors
Medical Sciences, 2018 Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid anti-tumor responses in the majority of patients with mutant BRAF melanoma, the tumors inevitably ...
Molly C. Peters +3 more
doaj +1 more source
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. [PDF]
PLoS ONE, 2010 Mast cell secretory granules accommodate a large number of components, many of which interact with highly sulfated serglycin proteoglycan (PG) present within the granules.
Gianni García-Faroldi +7 more
doaj +1 more source
Cancer Cell International, 2012 Background Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects.
Kjellström Johan +2 more
doaj +1 more source