Results 21 to 30 of about 1,000,648 (145)

Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. [PDF]

PLoS ONE, 2013
Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc.
Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala, Shailly Tomar   +4 more
doaj   +1 more source

TRPC1‐mediated Ca2+ signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding

Physiological Reports, 2021
Gut epithelial restitution after superficial wounding is an important repair modality regulated by numerous factors including Ca2+ signaling and cellular polyamines.
Navneeta Rathor, Hee Kyoung Chung, Jia‐Le Song, Shelley R. Wang, Jian‐Ying Wang, Jaladanki N. Rao   +5 more
doaj   +1 more source

Role of auxins, polyamines and ethylene in root formation and growth in sweet orange

Biologia Plantarum, 2011
The primary objective of this work was to investigate the role of polyamines (PAs) on root formation and growth in two sweet orange (Citrus sinensis L. Osb.) cultivars Pineapple and Pêra. Adventitious shoots (30-d-old) derived from epicotyl explants were
A. F. S. Mendes, L. C. Cidade, W. C. Otoni, W. S. Soares-Filho, M. G. C. Costa   +4 more
doaj   +1 more source

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. [PDF]

PLoS ONE, 2011
Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ...
Daniel P Barry, Mohammad Asim, David A Leiman, Thibaut de Sablet, Kshipra Singh, Robert A Casero, Rupesh Chaturvedi, Keith T Wilson   +7 more
doaj   +1 more source

Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells [PDF]

, 1998
We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 ...
Anwar R Baydoun, David M L Morgan, Baydoun, A. R., Morgan, D. M. L.   +3 more
core   +1 more source

Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
doaj   +1 more source

A novel mechanism of resistance to α-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine [PDF]

, 1986
Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of α-difluoromethylornithine ...
Burrone, O.R., Cafferata, E.G.A., Medrano, E.E., Ferrer, M.M., Algranati, I.D.   +4 more
core   +2 more sources

Polyamine depletion induces G₁ and S phase arrest in human retinoblastoma Y79 cells

Cancer Cell International, 2008
Background Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G1 arrest through dephosphorylation of retinoblastoma protein (pRb).
Kubota Shunichiro, Araie Makoto, Ueda Akiko   +2 more
doaj   +1 more source

Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin Cancer

, 2010
Perspective on this Article from A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of α-Difluoromethylornithine in Subjects with Previous History of Skin ...
Ajit K. Verma (15095274), David Puchalsky (15095298), Paul P. Carbone (15095307), Theresa Lenaghan (15095283), Mary Hamielec (15095289), Thomas C. Havighurst (15095304), Nancy E. Dreckschmidt (15095286), Harry H. Sharata (15095295), Howard H. Bailey (15095271), Jeff Douglas (5116172), Eric R. Berg (15095301), Paul O. Larson (15095280), Jaye L. Viner (14977705), KyungMann Kim (6468221), Stephen Snow (9105590), Marcy Pomplun (15095292), Karen Sielaff (15095277)   +16 more
core   +1 more source

KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation.

PLoS ONE, 2020
Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation.
Kazuhiro Nishimura, Moemi Okamoto, Rina Shibue, Toshio Mizuta, Toru Shibayama, Tetsuhiko Yoshino, Teruki Murakami, Masashi Yamaguchi, Satoshi Tanaka, Toshihiko Toida, Kazuei Igarashi   +10 more
doaj   +1 more source