Results 31 to 40 of about 67 (67)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 199, Issue 3, Page 183-188, September 2025.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages

Redox Biology
Salmonella infection entails a cascade of attacks and defence measures. After breaching the intestinal epithelial barrier, Salmonella is phagocytosed by macrophages, where the bacteria encounter multiple stresses, to which it employs relevant ...
Abhilash Vijay Nair, Anmol Singh, R.S. Rajmani, Dipshikha Chakravortty   +3 more
doaj   +1 more source

Insight into the functional and structural relationship of ornithine decarboxylase and its mutants from Lacticaseibacillus rhamnosus

Bulletin of the Korean Chemical Society, Volume 46, Issue 7, Page 730-742, July 2025.
Structural and functional analysis of Lactaseibacillus rhamnosus ODC highlights a key residue influencing PLP binding, enzymatic activity, and crystal structure, providing insight into its catalytic mechanism. Abstract Ornithine decarboxylase (ODC) is a critical enzyme in the polyamine biosynthesis pathway that catalyzes the conversion of l‐ornithine ...
Nonvide Nicolas Adiko, Hyeon Tae Seo, Dae‐Won Ki, Jung Hee Park, Da Som Kim   +4 more
wiley   +1 more source

Effect on Arabica Coffee Flavor Quality of Enhanced Fermentation With Pichia membranifaciens Through Change Microbial Communities and Chemical Compounds

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Weissella, Lactococcus, Trichococcus, Leuconostoc, and Massila at the bacterial general level and Pichia, Hanseniaspora, Lachancea, Candida, and Cystofilobasidium at the fungi general level were the predominant microorganisms during the enhanced fermentation of Arabica coffee.
Xiaojing Shen, Qi Wang, Jia Zheng, Xingyu Li, Song Li, Yanhua Yin, Mengli Shang, Kunyi Liu, Wenjuan Yuan, Jilai Zhang   +9 more
wiley   +1 more source

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers

Ibrain, Volume 11, Issue 2, Page 119-145, Summer 2025.
This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino, Annalisa Bianco, Valeria De Matteis, Edoardo Scarpa, Rosaria Rinaldi   +4 more
wiley   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang   +10 more
wiley   +1 more source

Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications

Small Science, Volume 5, Issue 4, April 2025.
In this article, the pivotal role of micropillars in cell mechanobiology is explored, detailing their design, fabrication, and characterization. Novel applications in biosensing are highlighted, emphasizing their ability to modulate cellular environments and facilitate mechano‐stimulation.
Prabuddha De Saram, Nam‐Trung Nguyen, Sina Jamali, Navid Kashaninejad   +3 more
wiley   +1 more source

In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation

Amino Acids
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme ornithine decarboxylase (ODC) of polyamine biosynthesis, α-difluoromethylornithine (DFMO), are implicated ...
Chien-Ching Lee, Chia-Chun Chuang, Chung-Hwan Chen, Yuan-Pin Huang, Chiao-Yi Chang, Pei-Yi Tung, Mon-Juan Lee   +6 more
doaj   +1 more source

The Role of the Urea Cycle in the Alzheimer's Disease Brain

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
Alzheimer's Disease (AD) is the leading cause of dementia, characterized by the accumulation of β‐amyloid plaques and neurofibrillary tangles in the brain. Despite extensive research, these hallmarks have not yet yielded effective therapies. Recent studies associate metabolic dysfunctions with AD, including elevated urea and ammonia, suggestive of a ...
Najlaa A. Al‐Thani, Gavin S. Stewart, Derek A. Costello   +2 more
wiley   +1 more source