Results 31 to 40 of about 1,000,648 (145)

Α-difluoromethylornithine (DFMO) treatment decreases meprin α expression in MDA-MB-435 cells, but not in MDA-MB-231 cells

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

Medical Sciences, 2018
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts   +4 more
doaj   +1 more source

Thrombocytopenia and Vomiting Due to Difluoromethylornithine

, 1987
A 32-year-old Haitian male with acquired immunodeficiency syndrome presented with complications of Isospora belli enteritis. Therapy with the investigational drug difluoromethylornithine was initiated.
Ellen M. Cosgrove, Karen J. Tietze, Janice A. Gaska   +2 more
core   +1 more source

Α-Difluoromethylornithine (DFMO) treatment affects both cell proliferation and cell death in MDA-MB-231 orthotopic tumors

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2013
Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents.
Altaf Mohammed, Naveena B Janakiram, Misty Brewer, Krishna Vedala, Vernon E Steele, Chinthalapally V Rao   +5 more
doaj   +1 more source

Electrochemistry of the Anticancer Agents Methotrexate and α-Difluaromethylornithine in lminium Form

, 1988
The electrochemical characteristics of the antitumor agents methotrexate and α-difluoromethylornithine were determined as their iminium derivatives. Iminium formation from methotrexate is accomplished in vivo via protonation by enzyme.
Ryan, Michael D., Taylor, Edward C, Ames, James R., Kovacic, Peter   +3 more
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, Volume 13, Issue 61, 3 November 2026.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Novel Water‐Soluble, Heavy Atom‐Free Thioxanthene‐Fused Naphthalimide–Polyamine Phototheranostic Conjugates

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Water‐soluble, heavy‐atom‐free naphthalimide–polyamine conjugates were developed as novel phototheranostic agents. Conjugates 2 and 3 showed effective photocytotoxicity in MCF‐7 cells with negligible dark toxicity. Fluorescence imaging confirmed efficient cellular uptake.
Elisa Uliassi, Michele Rossi, Matteo Di Giosia, Amalia Conti, Matteo Calvaresi, Kerry J. Rhoden, Maria Laura Bolognesi   +6 more
wiley   +1 more source

Isolation and characterization of human breast adenocarcinoma cells made resistant to α-difluoromethylornithine

, 2000
Human breast adenocarcinoma cells MCF-7 were selected for resistance to ornithine decarboxylase (ODC) inhibitor, α-difluoromethylornithine (DFMO). Stepwise increments of the concentration of DFMO resulted in selection of MCF-7 cells that were capable of ...
Khurana, Kamal K., Das, Bhagwan, Vig, Monika, Madhubala, Rentala   +3 more
core   +1 more source