Results 51 to 60 of about 1,000,648 (145)
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham +15 more
wiley +1 more source
Properties of L1210 cells resistant to α-difluoromethylornithine
, 1988 L1210 cells were selected for resistance to the ornithine decarboxylase (ODC) inhibitor, α-difluromethylornithine. When grown in the absence of the inhibitor, these cells possessed very high ornithine decarboxylase levels.
Madhubala, Rentala +2 more
core +1 more source
Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo +13 more
wiley +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source
, 2011 Supplementary Figure 1 from Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in ...
Gang Xie (162461) +8 more
core +1 more source
Cancer Science, Volume 116, Issue 11, Page 3079-3089, November 2025.Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Xue‐Chen Wei +7 more
wiley +1 more source
Biotechnologie, Agronomie, Société et Environnement, 2014 Effect of polyamines on the reduction of hexavalent chromium by bacterial strains and their resistance. Polyamines are involved in several functions in bacteria.
Tahri Joutey, N. +3 more
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Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Advanced Science, Volume 12, Issue 40, October 27, 2025.Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou +7 more
wiley +1 more source