Results 11 to 20 of about 67 (67)

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas

CNS Oncology, 2018
This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin, Sandra E Ictech, Kenneth R Hess   +2 more
doaj   +1 more source

Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion

Cancer Cell International, 2012
Background Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects.
Kjellström Johan, Oredsson Stina M, Wennerberg Johan   +2 more
doaj   +1 more source

Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells

Frontiers in Oncology, 2021
Personized treatment of breast cancer is still a challenge, and more treatment options for breast cancer are warranted. Combination therapies have been a highly appreciated strategy for breast cancer treatment in recent years, and the development of new ...
Hongyan Ma, Hongyan Ma, Hongyan Ma, Qizhang Li, Qizhang Li, Jing Wang, Jing Wang, Jing Wang, Jing Pan, Jing Pan, Jing Pan, Zhengding Su, Zhengding Su, Sen Liu, Sen Liu, Sen Liu   +15 more
doaj   +1 more source

Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. [PDF]

PLoS ONE, 2013
Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc.
Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala, Shailly Tomar   +4 more
doaj   +1 more source

TRPC1‐mediated Ca2+ signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding

Physiological Reports, 2021
Gut epithelial restitution after superficial wounding is an important repair modality regulated by numerous factors including Ca2+ signaling and cellular polyamines.
Navneeta Rathor, Hee Kyoung Chung, Jia‐Le Song, Shelley R. Wang, Jian‐Ying Wang, Jaladanki N. Rao   +5 more
doaj   +1 more source

Role of auxins, polyamines and ethylene in root formation and growth in sweet orange

Biologia Plantarum, 2011
The primary objective of this work was to investigate the role of polyamines (PAs) on root formation and growth in two sweet orange (Citrus sinensis L. Osb.) cultivars Pineapple and Pêra. Adventitious shoots (30-d-old) derived from epicotyl explants were
A. F. S. Mendes, L. C. Cidade, W. C. Otoni, W. S. Soares-Filho, M. G. C. Costa   +4 more
doaj   +1 more source

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. [PDF]

PLoS ONE, 2011
Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ...
Daniel P Barry, Mohammad Asim, David A Leiman, Thibaut de Sablet, Kshipra Singh, Robert A Casero, Rupesh Chaturvedi, Keith T Wilson   +7 more
doaj   +1 more source

Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
doaj   +1 more source

Polyamine depletion induces G₁ and S phase arrest in human retinoblastoma Y79 cells

Cancer Cell International, 2008
Background Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G1 arrest through dephosphorylation of retinoblastoma protein (pRb).
Kubota Shunichiro, Araie Makoto, Ueda Akiko   +2 more
doaj   +1 more source

KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation.

PLoS ONE, 2020
Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation.
Kazuhiro Nishimura, Moemi Okamoto, Rina Shibue, Toshio Mizuta, Toru Shibayama, Tetsuhiko Yoshino, Teruki Murakami, Masashi Yamaguchi, Satoshi Tanaka, Toshihiko Toida, Kazuei Igarashi   +10 more
doaj   +1 more source