Results 31 to 40 of about 3,690 (206)
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
EMBO Molecular Medicine, 2023 Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and
Tracy Murray Stewart +8 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Current treatments of hepatitis B virus (HBV) are limited to Interferon-alpha or the nucleos(t)ide analogs antiviral therapies, and it is crucial to develop and define new antiviral drugs to cure HBV.
Binli Mao +7 more
doaj +1 more source
The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. [PDF]
PLoS ONE, 2012 Exposure to uncontrolled irradiation in a radiologic terrorism scenario, a natural disaster or a nuclear battlefield, will likely be concomitantly superimposed on other types of injury, such as trauma.
Susanna Rosi +5 more
doaj +1 more source
PLoS ONE, 2020 Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation.
Kazuhiro Nishimura +10 more
doaj +1 more source
Viability of parasites treated with HYD and DFMO.
, 2020 Viability of parasites treated with HYD and DFMO.
Oluyomi Stephen Adeyemi (6733613) +6 more
core +1 more source
Medical Sciences, 2018 The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.
Nicole LoGiudice +4 more
doaj +1 more source
Effect of DFMO and spermine supplementation on Dnmt activity.
, 2013 DFMO decreased, while spermine supplementation increased Dnmt activity in Jurkat cells. Mean ±standard deviation; n = number of experiments as indicated. no treatment (control): cells cultured in culture medium. DFMO: cells cultured with 3 mM DMFO.
Fumio Konishi (283703) +2 more
core +1 more source
, 2014 DFMO, a trypanostatic drug, presents a satisfactory intestinal absorption but its elimination from the blood is rapid so that high doses are necessary to obtain a therapeutic effect.
O. Chauffert +4 more
core +1 more source
Effect of DFMO and spermine supplementation on Active Rap-1 protein levels.
, 2013 Neither DFMO nor spermine activated Rap-1. negative control: cell lysate treated with GDP. positive control: cell lysate treated with GTP-gamma-S. no treatment: cell lysate with no treatment. DFMO: lysate of cells cultured with 3 mM DMFO.
Fumio Konishi (283703) +2 more
core +1 more source
Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. [PDF]
PLoS ONE, 2015 The prostate is a male accessory sex gland that produces secretions in seminal fluid to facilitate fertilization. Prostate secretory function is dependent on androgens, although the mechanism by which androgens exert their effects is still unclear ...
Melissa Gamat +4 more
doaj +1 more source