Results 41 to 50 of about 2,373 (170)

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Medical Sciences, 2018
Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynthesis
Rebecca R. Weicht, Chad R. Schultz, Dirk Geerts, Katie L. Uhl, André S. Bachmann   +4 more
doaj   +1 more source

Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. [PDF]

PLoS ONE, 2013
Spermine and spermidine, natural polyamines, suppress lymphocyte function-associated antigen 1 (LFA-1) expression and its associated cellular functions through mechanisms that remain unknown.
Yoshihiko Kano, Kuniyasu Soda, Fumio Konishi   +2 more
doaj   +1 more source

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park, Suyeon Yellena Kim, C. Justin Lee   +2 more
doaj   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme. [PDF]

PLoS Neglected Tropical Diseases, 2008
BACKGROUND: The polyamines putrescine, spermidine, and spermine are organic cations that are required for cell growth and differentiation. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is a ...
Anupam Jhingran, Prasad K Padmanabhan, Sushma Singh, Krishanpal Anamika, Abhijeet A Bakre, Sudha Bhattacharya, Alok Bhattacharya, Narayanaswamy Srinivasan, Rentala Madhubala   +8 more
doaj   +1 more source

Optical Skyrmions with Tunable or Reconfigurable Topology Using Spin‐Decoupled Metaoptics

Laser &Photonics Reviews, Volume 20, Issue 14, 22 July 2026.
The work introduces advanced optical elements capable of generating and dynamically reconfiguring complex light patterns known as optical skyrmions. By precisely shaping light polarization at the nanoscale, a single engineered metasurface can generate and manipulate robust and tunable polarization textures in an efficient and scalable way.
Andrea Vogliardi, Daniele Bonaldo, Simone Dal Zilio, Vittorio Apolloni, Filippo Romanato, Gianluca Ruffato   +5 more
wiley   +1 more source

Testosterone as Diamine Oxidase Activity Regulator [PDF]

BioDiscovery, 2017
Diamine oxidase (DAO) is a key enzyme of the metabolism of polyamines. Its activity was assayed in homogenate of male immature rat liver and kidney.  The androgens are important regulators of polyamines’ metabolism.
Milena Mishonova, Hristo Gagov
doaj   +3 more sources

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source