Results 41 to 50 of about 3,690 (206)
Combinatorial treatment of DFMO and diclofenac decreases EMT processes.
, 2013 (A) The effect of DFMO+diclofenac treatment on levels of epithelial marker, E-cadherin and mesenchymal markers, vimentin and fibronectin in A431 xenograft tumors. (B) Western blot analysis of EMT transcription factors snail (@ = NS, # = 0.03, $ = 0.004, &
Zhiping Weng (51233) +7 more
core +1 more source
Study Safety Data: Toxicity of Oral DFMO and Etoposide.
, 2015 Percentages are calculated as number of patients with an event divided by number of patients in group that received drug.ALT = alanine aminotransferaseAST = aspartate aminotransferaseGGT = gamma-glutamyl transpeptidaseAdverse events attributed (possibly,
Alyssa VanderWerff (745743) +21 more
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The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
, 2013 Polyamine concentrations in Jurkat cells cultured for 72 h in 3 conditions. Mean ± standard deviation. n = number of experiments. control: cells cultured in RPMI 1640 with 10% human serum. DFMO: cells treated with 3 mM DMFO.
Fumio Konishi (283703) +2 more
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Ornithine decarboxylase as a therapeutic target for endometrial cancer. [PDF]
PLoS ONE, 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and
Hong Im Kim +9 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: Polyamines have been demonstrated to be beneficial to porcine intestinal development. Our previous study showed that putrescine mitigates intestinal atrophy in weanling piglets and suppresses inflammatory response in porcine intestinal ...
Zi-xi Wei +4 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
, 2014 Visceral leishmaniasis (VL) caused by Leishmania donovani is a systemic protozoan disease that is fatal if left untreated. The promastigote form of L.
Singh, Alok Kumar +3 more
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Combination effect of HYD or DFMO with either DA, ATV, or CLF in vitro.
, 2020 Combination effect of HYD or DFMO with either DA, ATV, or CLF in vitro.
Oluyomi Stephen Adeyemi (6733613) +6 more
core +1 more source
Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant. [PDF]
PLoS ONE, 2013 The acquired mutation (V617F) of Janus kinase 2 (JAK2) is observed in the majority of patients with myeloproliferative neoplasms (MPNs). In the screening of genes whose expression was induced by JAK2 (V617F), we found the significant induction of c-Myc ...
Megumi Funakoshi-Tago +3 more
doaj +1 more source