Results 61 to 70 of about 3,690 (206)

Testosterone as Diamine Oxidase Activity Regulator [PDF]

BioDiscovery, 2017
Diamine oxidase (DAO) is a key enzyme of the metabolism of polyamines. Its activity was assayed in homogenate of male immature rat liver and kidney.  The androgens are important regulators of polyamines’ metabolism.
Milena Mishonova, Hristo Gagov
doaj   +3 more sources

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source

Chemoprevention of Colon Cancer by DFMO, Sulindac, and NO-Sulindac Administered Individually or in Combinations in F344 Rats

, 2023
Non-steroidal anti-inflammatory drugs (NSAIDs) are promising colorectal cancer (CRC) chemopreventive drugs; however, to overcome NSAIDs’ associated side effects, there is a need to develop safer and efficacious approaches.
Stanley Lightfoot, Yuting Zhang, Altaf Mohammed, Venkateshwar Madka, Jagan M. R. Patlolla, Naveena B. Janakiram, Gopal Pathuri, Karthikkumar Venkatachalam, Nicole Stratton, Chinthalapally V. Rao   +9 more
core   +1 more source

Novel Water‐Soluble, Heavy Atom‐Free Thioxanthene‐Fused Naphthalimide–Polyamine Phototheranostic Conjugates

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Water‐soluble, heavy‐atom‐free naphthalimide–polyamine conjugates were developed as novel phototheranostic agents. Conjugates 2 and 3 showed effective photocytotoxicity in MCF‐7 cells with negligible dark toxicity. Fluorescence imaging confirmed efficient cellular uptake.
Elisa Uliassi, Michele Rossi, Matteo Di Giosia, Amalia Conti, Matteo Calvaresi, Kerry J. Rhoden, Maria Laura Bolognesi   +6 more
wiley   +1 more source

Α-Difluoromethylornithine (DFMO) (2% per orally in drinking water) decreases polyamine levels in mammary fat pad tumors of MDA-MB-231 cells

, 2011
Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425), Douglas J DiGirolamo (71573), Monica M Richert (63671), Andrea Manni (71577), Judith S Bond (71576), Laurence M Demers (71575), Pushkar A Phadke (71571), Gail Matters (71572), Sharlene Washington (71574)   +8 more
core   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Curcumin cooperates with DFMO to inhibit cell growth.

, 2018
MTS cell proliferation assays revealed enhanced growth inhibition when combining curcumin with the ODC inhibitor DFMO in AGS (A) and HCT116 (B) cells.
Yuan Lui (5680445), Matthew Dunworth (4424164), Robert A. Casero Jr (178905), Tracy Murray-Stewart (659215), Patrick M. Woster (1305114), Francis M. Giardiello (5680448)   +5 more
core   +1 more source

Optical Skyrmions with Tunable or Reconfigurable Topology Using Spin‐Decoupled Metaoptics

Laser &Photonics Reviews, Volume 20, Issue 14, 22 July 2026.
The work introduces advanced optical elements capable of generating and dynamically reconfiguring complex light patterns known as optical skyrmions. By precisely shaping light polarization at the nanoscale, a single engineered metasurface can generate and manipulate robust and tunable polarization textures in an efficient and scalable way.
Andrea Vogliardi, Daniele Bonaldo, Simone Dal Zilio, Vittorio Apolloni, Filippo Romanato, Gianluca Ruffato   +5 more
wiley   +1 more source

Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion

Cancer Cell International, 2012
Background Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects.
Kjellström Johan, Oredsson Stina M, Wennerberg Johan   +2 more
doaj   +1 more source

Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes

Cellular Physiology and Biochemistry, 2014
Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in polyamine synthesis and endoplasmic reticulum stress (ERS) in ...
Yan Lin, Xiaojie Zhang, Lina Wang, Yajun Zhao, Hongzhu Li, Wei Xiao, Changqing Xu, Jicheng Liu   +7 more
doaj   +1 more source