Results 61 to 70 of about 2,363 (167)

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

npj Precision Oncology, 2017
Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He, Eunmiri Roh, Ke Yao, Kangdong Liu, Xing Meng, Fangfang Liu, Penglei Wang, Ann M. Bode, Zigang Dong   +8 more
doaj   +1 more source

Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation

Animal Nutrition, 2020
l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC). Polyamines plays a key role in the proliferation of intestinal epithelial cells.
Jing Wang, Bi'e Tan, Jianjun Li, Xiangfeng Kong, Minjie Tan, Guoyao Wu   +5 more
doaj   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors. [PDF]

PLoS ONE, 2014
In Alzheimer's disease (AD), the β-amyloid peptide (Aβ) has been causally linked to synaptic dysfunction and cognitive impairment. Several studies have shown that N-Methyl-D-Aspartate receptors (NMDAR) activation is involved in the detrimental actions of
Guilherme Monteiro Gomes, Gerusa Duarte Dalmolin, Julia Bär, Anna Karpova, Carlos Fernando Mello, Michael R Kreutz, Maribel Antonello Rubin   +6 more
doaj   +1 more source

ODC‐Driven Polyamines Synthesis Sustains the Self‐Renewal of Glioblastoma Stem Cells and Drives Tumor Aggressiveness

Cancer Science, Volume 116, Issue 11, Page 3079-3089, November 2025.
Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Xue‐Chen Wei, Hao‐Qian Zhang, Guang‐Qin Liu, Chang‐Wei Liu, Ai‐ling Li, Xin Pan, Wei‐Qun Yan, Jia‐Yi Chen   +7 more
wiley   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Effets de la difluorométhylornithine après administration intraveineuse et son association avec de l'acéturate de diminazène contre Trypanosoma bruceichez des chiens infectés expérimentalement au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1997
De la difluorométhylornithine (DFMO, eflornithine) a été donnée par voie intraveineuse (lV) à des chiens infectés expérimentalement par Trypanosoma brucei.
B.M. Anene, S.M. Anika, C.C. Chukwu
doaj   +1 more source

A Case of APC Gene Mutation‐Associated Familial Adenomatous Polyposis With Multiple System Malignancies

Cancer Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, with a nearly 100% risk of developing colorectal cancer by the age of 40. The primary gene mutated in FAP is APC, and mutations in certain regions of the APC gene may be associated with thyroid disorders, including malignant neoplasms, benign nodules ...
Ren Yijing, Wang Wenjun, Gao Xiang, Xing Kongling, Chen Yunxia, Liao Wei, Zhou Ping   +6 more
wiley   +1 more source

Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
D,L-alpha-difluoromethylornithine (DFMO) was synthesized over 20 years ago. It was hoped that this enzyme-activated, irreversible inhibitor of ornithine decarboxylase, the first enzyme in polyamine synthesis, would be effective as a chemotherapy for hyperproliferative diseases, including cancer and/or infectious processes.
Meyskens, F L, Jr, Gerner, E W
openaire   +2 more sources

New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II ...
Jessica D. Daley, Susan L. Whiteway, Christine M. Heske, Filemon S. Dela Cruz, Sarah B. Whittle, Sarah Cohen‐Gogo, Anderson B. Collier, Ajay Gupta, Joyce Ohm, Andrew Clark, Alice Soragni, Elizabeth Lawlor, Bhuvana Setty, Patrick J. Grohar, Katie Janeway, Damon R. Reed, Emily K. Slotkin, Kelly M. Bailey   +17 more
wiley   +1 more source