Results 71 to 80 of about 2,363 (167)

Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.

The Journal of biological chemistry, 2005
L-Alpha-difluoromethylornithine (DFMO) is a chemopreventive agent for colon cancer in clinical trials. Yet, the drug produces an across-frequency elevation of the hearing threshold, suggesting that DFMO may affect a common trait along the cochlear spiral. The mechanism for the ototoxic effects of DFMO remains uncertain. The cochlear duct is exclusively
Liping, Nie, Weihong, Feng, Rodney, Diaz, Michael A, Gratton, Karen Jo, Doyle, Ebenezer N, Yamoah   +5 more
openaire   +1 more source

Insight into the functional and structural relationship of ornithine decarboxylase and its mutants from Lacticaseibacillus rhamnosus

Bulletin of the Korean Chemical Society, Volume 46, Issue 7, Page 730-742, July 2025.
Structural and functional analysis of Lactaseibacillus rhamnosus ODC highlights a key residue influencing PLP binding, enzymatic activity, and crystal structure, providing insight into its catalytic mechanism. Abstract Ornithine decarboxylase (ODC) is a critical enzyme in the polyamine biosynthesis pathway that catalyzes the conversion of l‐ornithine ...
Nonvide Nicolas Adiko, Hyeon Tae Seo, Dae‐Won Ki, Jung Hee Park, Da Som Kim   +4 more
wiley   +1 more source

Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma.

Translational pediatrics, 2016
Neuroblastoma is a childhood tumor in which MYC oncogenes are commonly activated to drive tumor progression. Survival for children with high-risk neuroblastoma remains poor despite treatment that incorporates high-dose chemotherapy, stem cell support, surgery, radiation therapy and immunotherapy.
Bassiri, Hamid, Benavides, Adriana, Haber, Michelle, Gilmour, Susan K, Norris, Murray D, Hogarty, Michael D   +5 more
openaire   +2 more sources

Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems

Medical Sciences, 2017
Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang, Otto Phanstiel, Laurence von Kalm   +2 more
doaj   +1 more source

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Frontiers in Oncology, 2012
Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble, Michael D Hogarty, Xuenyuan eLiu, David S Ziegler, David S Ziegler, Glenn M Marshall, Glenn M Marshall, Murray D Norris, Michelle eHaber   +8 more
doaj   +1 more source

Effect of α-difluormethylornithine on Anastrepha fraterculus (Diptera, Tephritidae) ovary size Efeito da α-difluorometilornitina nas dimensões dos ovários em Anastrepha fraterculus (Diptera, Tephritidae)

Brazilian Journal of Biology, 2009
Ovarian sizes (length and width) were measured in young females of Anastrepha fraterculus (Wiedemann) (Diptera, Tephritidae) subjected or not to the inhibitor α -difluormethylornithine (α -DFMO). The most effective concentration of α -DMFO
VV. Cardoso, JCF. Moreira, AK. Oliveira
doaj   +1 more source

The influence of chemical analogs of decarboxylated ornithine and S-(adenosil)-methionine on the growth of L-cell tissue culture

RUDN Journal of Medicine, 2010
The effect of aliphatic amino- and oxy-derivatives of Ornithine and of S-(Adenosil)-methionine on the growth of L-cells in tissue culture was studied.
S P Siatkin, T T Berezov, T V Fedoronchuk, N Ya Gridina, E A Neborakh, N A Shevkhun, N A Sokueva, E V Ustinova, R I Sokuev   +8 more
doaj  

Chemopreventionof long-term oncological consequences on the model of radiation carcinogenesis in female rats

Сибирский онкологический журнал, 2016
A comparative study of the anticarcinogenic activity of synthetic polyamine inhibitor α-difluoromethylornithine (DFMO) and three plant drugs on the model of radiation carcinogenesis was carried out in 615 female Wistar rats subjected to total body γ ...
V. G. Bespalov, A. V. Alexandrov, A. L. Semenov, E. G. Kovanko, S. D. Ivanov   +4 more
doaj  

Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae

Biomolecules
Streptococcus pneumoniae (Spn), a Gram-positive bacterium, poses a significant threat to human health, causing mild respiratory infections to severe invasive conditions. Despite the availability of vaccines, challenges persist due to serotype replacement
Moses B. Ayoola, Leslie A. Shack, Otto Phanstiel, Bindu Nanduri   +3 more
doaj   +1 more source

Effect of alpha-difluoromethylornithine (DFMO) on the growth of human ovarian carcinoma.

European journal of gynaecological oncology, 1988
The antiproliferative effect of alpha-difluoromethylornithine (DFMO) was investigated in a human ovarian cancer cell line (NIH:OVCAR3) both in vitro and in vivo. DFMO at 5 X 10(-5) M, 5 X 10(-4) M and 1 X 10(-3) M concentrations showed growth inhibition of NIH:OVCAR3 cells in culture. Parallel determination of CA 125 in the culture media of these cells
A, Manetta, P G, Satyaswarcoop, E S, Podczaski, T, Hamilton, R F, Ozols, R, Mortel   +5 more
openaire   +1 more source