Results 91 to 100 of about 3,690 (206)
Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham +15 more
wiley +1 more source
Transcriptomic analysis of DFMO treated cells.
, 2023 Huh7 cells were treated with 1mM DFMO for 96h and subjected to RNA sequencing. Results are based on duplicates. (A) GSEA was conducted on genes differentially expressed by 1mM DFMO treated Huh7 versus untreated Huh7.
Bryan C. Mounce (15314753) +4 more
core +1 more source
The Journal of biological chemistry, 2005 L-Alpha-difluoromethylornithine (DFMO) is a chemopreventive agent for colon cancer in clinical trials. Yet, the drug produces an across-frequency elevation of the hearing threshold, suggesting that DFMO may affect a common trait along the cochlear spiral. The mechanism for the ototoxic effects of DFMO remains uncertain. The cochlear duct is exclusively
Liping, Nie +5 more
openaire +1 more source
Combined effects of DFMO+diclofenac inhibit the growth of A431 xenograft tumors.
, 2013 (A) Tumor growth curve and end-point tumor volume at day 15 in A431 xenografts (n = 10) treated with DFMO and diclofenac as individual agent and in combination.
Zhiping Weng (51233) +7 more
core +1 more source
Α-Difluoromethylornithine (DFMO) delays orthotopic tumor growth of MDA-MB-231 cells
, 2011 Copyright information:Taken from "Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment"Breast Cancer Research 2005;7(5):R819-R827.Published online 9 Aug 2005PMCID:PMC1242150.Copyright © 2005
Danny R Welch (8425) +8 more
core +1 more source
, 2013 (A) Tissue sections from A431 xenograft tumors were stained for PCNA or TUNEL. DFMO+diclofenac treatment on expression levels of PCNA and TUNEL-positive apoptotic cells as compared to vehicle and their individual treatments. (B) Western blot analysis was
Zhiping Weng (51233) +7 more
core +1 more source
Medical Sciences, 2017 Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang +2 more
doaj +1 more source
DFMO+diclofenac decrease the expression levels of ODC and COX-2 through Akt and ERK signaling axis.
, 2013 (A) Western blot analysis showing expression of ODC and COX-2. The bar diagram represents relative expression levels of these proteins (ODC: @ = 0.04, # = NS, $ = 0.01, & = NS, ? = 0.02; COX-2: @ = NS, # = 0.04, $ = 0.008, & = 0.003 ? = NS).
Zhiping Weng (51233) +7 more
core +1 more source
Brazilian Journal of Biology, 2009 Ovarian sizes (length and width) were measured in young females of Anastrepha fraterculus (Wiedemann) (Diptera, Tephritidae) subjected or not to the inhibitor α -difluormethylornithine (α -DFMO). The most effective concentration of α -DMFO
VV. Cardoso, JCF. Moreira, AK. Oliveira
doaj +1 more source
Urinary polyamine metabolites from patients at baseline and during first two weeks of DFMO therapy.
, 2015 C1D1 = cycle 1 day 1 (defined as baseline)C1D8 = cycle 1 day 8 after starting DFMO on day1C1D15 = cycle 1 day 15 after starting DFMO on day 1*Determined by Friedman two-way analysis of variance**Not significantUrinary polyamine metabolites from patients ...
Alyssa VanderWerff (745743) +21 more
core +1 more source