Results 101 to 110 of about 3,690 (206)
Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma
Frontiers in Oncology, 2012 Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble +8 more
doaj +1 more source
Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma.
Translational pediatrics, 2016 Neuroblastoma is a childhood tumor in which MYC oncogenes are commonly activated to drive tumor progression. Survival for children with high-risk neuroblastoma remains poor despite treatment that incorporates high-dose chemotherapy, stem cell support, surgery, radiation therapy and immunotherapy.
Bassiri, Hamid +5 more
openaire +2 more sources
RUDN Journal of Medicine, 2010 The effect of aliphatic amino- and oxy-derivatives of Ornithine and of S-(Adenosil)-methionine on the growth of L-cells in tissue culture was studied.
S P Siatkin +8 more
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A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma. [PDF]
, 1986 Difluoromethylornithine (DFMO) is an irreversible enzyme-activated inhibitor of ornithine decarboxylase, a key enzyme in polyamine synthesis. We have screened for potential anti-cancer activity of DFMO using a clonogenic assay, which suggested that ...
Meyskens, F L +4 more
core +1 more source
, 2015 Flowchart of NMTRC 002—Safety Study for Refractory or Relapsed Neuroblastoma With DFMO Alone and in Combination With Etoposide.
Alyssa VanderWerff (745743) +21 more
core +1 more source
Cell number and morphology of BMMCs in the absence or presence of DFMO.
, 2020 (A) Starting with 0.1 mM DFMO treatment from day 3, the cells were cultured until day 28. The relative cell number on day 0 is shown as 1. Standard deviation (s.d.) was calculated; n = 3 replicates. *p < 0.05 compared with control.
Toru Shibayama (8496030) +10 more
core +1 more source
Development and evaluation of polymeric hybrid a-Difluoromethylornithine (DFMO) & Etoposide loaded nanocarriers for the treatment of Neuroblastoma [PDF]
, 2016 Neuroblastoma (NB) is the most common extra-cranial solid cancer in childhood and infancy with patients having an average age of 17 months. Most are diagnosed with advanced stage NB when tumor progression is aggressive, making treatment of NB even more ...
Glasgow, Micah David Kealaka'i
core
, 1985 Topical methylglyoxal bis(guanylhydrazone) (MGBG) and alpha-difluoromethylornithine (DFMO) individually have been shown to produce partial clinical improvement in psoriasis.
Klein, Jeffrey +4 more
core +1 more source
The role of DFMO in Helicobacter pylori infection: modulation of ROS response
, 2018 Background: Gastric cancer remains the third foremost cause of cancer deaths worldwide. The leading cause of gastric cancer, Helicobacter pylori is a thought drive carcinogenesis by inducing chronic inflammation. One pathway implicated in the host immune
Baker, Dara, Sierra, J. Carolina
core
Сибирский онкологический журнал, 2016 A comparative study of the anticarcinogenic activity of synthetic polyamine inhibitor α-difluoromethylornithine (DFMO) and three plant drugs on the model of radiation carcinogenesis was carried out in 615 female Wistar rats subjected to total body γ ...
V. G. Bespalov +4 more
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