Results 51 to 60 of about 3,690 (206)

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Medical Sciences, 2018
Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynthesis
Rebecca R. Weicht, Chad R. Schultz, Dirk Geerts, Katie L. Uhl, André S. Bachmann   +4 more
doaj   +1 more source

Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. [PDF]

PLoS ONE, 2013
Spermine and spermidine, natural polyamines, suppress lymphocyte function-associated antigen 1 (LFA-1) expression and its associated cellular functions through mechanisms that remain unknown.
Yoshihiko Kano, Kuniyasu Soda, Fumio Konishi   +2 more
doaj   +1 more source

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park, Suyeon Yellena Kim, C. Justin Lee   +2 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Changes in methylation status of ITGAL promoter by DFMO and spermine supplementation.

, 2013
Bisulfite sequencing was performed to determine the methylation pattern of the Jurkat cell ITGAL promoter, numbered relative to the transcription start site. Left: methylation status of each CpG dimer in 4 segments of sequential fragments.
Fumio Konishi (283703), Yoshihiko Kano (283699), Kuniyasu Soda (283701)   +2 more
core   +1 more source

IC₅₀ and selective index values of HYD and DFMO.

, 2020
IC50 and selective index values of HYD and DFMO.
Oluyomi Stephen Adeyemi (6733613), Eman Rashwan (8447058), Ikuo Igarashi (497111), Eman Nadwa (8447055), Gaber El-Saber Batiha (6733604), Amany Magdy Beshbishy (6733607), Naoaki Yokoyama (173586)   +6 more
core   +1 more source

Natural and DFMO-induced transformation of Trypanosoma brucei: a comparison of several biochemical parameters [PDF]

, 1992
Morphological and biochemical transformation of bloodstream form trypanosomes from long slender (LS) to short stumpy (SS) forms is an important event for completion of the trypanosome life cycle because it pre-adapts the trypanosome for the change of ...
Hartman, Scott Michael
core   +1 more source

Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme. [PDF]

PLoS Neglected Tropical Diseases, 2008
BACKGROUND: The polyamines putrescine, spermidine, and spermine are organic cations that are required for cell growth and differentiation. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is a ...
Anupam Jhingran, Prasad K Padmanabhan, Sushma Singh, Krishanpal Anamika, Abhijeet A Bakre, Sudha Bhattacharya, Alok Bhattacharya, Narayanaswamy Srinivasan, Rentala Madhubala   +8 more
doaj   +1 more source

IN-VIVO EFFECTS OF 4-AMIDINOINDAN-1-ONE 2'-AMIDINOHYDRAZONE (CGP 48664A) AND ALPHA-DIFLUOROMETHYLORNITHINE (DFMO) ON L1210 GROWTH, CELL-CYCLE PHASE DISTRIBUTION AND POLYAMINE CONTENTS

, 1995
We studied the in vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), alpha-difluoromethylornithine (DFMO) and a combination of CGP 48654A-DFMO on tumor growth, cell-cycle phase distribution and polyamine contents.
TEVELDE, RJ, Te Velde, Roelf Jakob, MUSKIET, FAJ, Ferwerda, Harri, DORHOUT, B, Kingma, Anneke W., Dorhout, Bernard, DEHOOG, E, FERWERDA, H, De Hoog, Elly, Muskiet, Frits A. J., KINGMA, AW   +11 more
core   +1 more source

The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma

Molecular Oncology
High‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning.
Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers   +19 more
doaj   +1 more source