Results 51 to 60 of about 2,363 (167)

Sustained Delivery of Difluoromethylornithine (DFMO) by Means of Implantable Ceramic Devices

Journal of Investigative Surgery, 1988
A total of 25 Sprague-Dawley albino male rats were assigned to five groups, each group consisting of five rats. Polylactic acid-impregnated ALCAP capsules filled with 40 mg DFMO were implanted subcutaneously (sc) or intraperitoneally (ip) in group I and II rats, respectively.
H A, Benghuzzi, P K, Bajpai
openaire   +2 more sources

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma, Ting Pan, Shengli Sun, Musitapa Mutalifu, Wei Yang, Yue Niu, Peng Chen   +6 more
wiley   +1 more source

Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion

Cancer Cell International, 2012
Background Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects.
Kjellström Johan, Oredsson Stina M, Wennerberg Johan   +2 more
doaj   +1 more source

Effect of polyamine biosynthesis inhibitors on in vitro growth of Phyllosticta antirrhini Sydow and on the infection of Antirrhinum majus L. by the pathogen

Acta Agrobotanica, 2013
Polyamine biosynthesis inhibitors, DL-α-difluromethylornithine (DFMO) and DL-α-difluromethylarginine (DFMA) at concentrations of 1,0 and 3,0 mM greatly inhibited mycelial growth of Phyllosticta antirrhini on Czapek Dox Agar (CDA).
Alicja Saniewska
doaj   +1 more source

Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer's Disease: A Compassionate Use, Single-Case Study

Frontiers in Aging Neuroscience, 2018
Background: Recent genome-wide association screening (GWAS) studies have linked Alzheimer's disease (AD) neuropathology to gene networks that regulate immune function. Kan et al.
Jessica Alber, Jessica Alber, Kelly McGarry, Richard B. Noto, Peter J. Snyder, Peter J. Snyder, Peter J. Snyder   +6 more
doaj   +1 more source

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation

Amino Acids
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme ornithine decarboxylase (ODC) of polyamine biosynthesis, α-difluoromethylornithine (DFMO), are implicated ...
Chien-Ching Lee, Chia-Chun Chuang, Chung-Hwan Chen, Yuan-Pin Huang, Chiao-Yi Chang, Pei-Yi Tung, Mon-Juan Lee   +6 more
doaj   +1 more source

Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes

Cellular Physiology and Biochemistry, 2014
Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in polyamine synthesis and endoplasmic reticulum stress (ERS) in ...
Yan Lin, Xiaojie Zhang, Lina Wang, Yajun Zhao, Hongzhu Li, Wei Xiao, Changqing Xu, Jicheng Liu   +7 more
doaj   +1 more source

Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. [PDF]

PLoS ONE, 2013
Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc.
Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala, Shailly Tomar   +4 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source