Results 21 to 30 of about 2,373 (170)
Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO.
PLoS ONE, 2020 BackgroundAnti-GD2 therapy with dinutuximab is effective in improving the survival of high-risk neuroblastoma patients in remission and after relapse. However, allodynia is the major dose-limiting side effect, hindering its use for neuroblastoma patients
Mitchell B Diccianni +4 more
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Upregulation of Polyamine Transport in Human Colorectal Cancer Cells
Biomolecules, 2020 Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells.
Misael Corral, Heather M. Wallace
doaj +1 more source
Characterising the Response of Human Breast Cancer Cells to Polyamine Modulation
Biomolecules, 2021 Breast cancer is a complex heterogeneous disease with multiple underlying causes. The polyamines putrescine, spermidine, and spermine are polycationic molecules essential for cell proliferation. Their biosynthesis is upregulated in breast cancer and they
Oluwaseun Akinyele, Heather M. Wallace
doaj +1 more source
Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells
Cancer Cell International, 2008 Background Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G1 arrest through dephosphorylation of retinoblastoma protein (pRb).
Kubota Shunichiro +2 more
doaj +1 more source
Cancer Reports, 2022 Background Survival for patients with high‐risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapies. Aims To study the feasibility and safety of incorporating a genomic‐based targeted agent to induction therapy for HRNB as well as ...
Jacqueline M. Kraveka +23 more
doaj +1 more source
DFMO: Targeted risk reduction therapy for colorectal neoplasia [PDF]
Best Practice & Research Clinical Gastroenterology, 2011 Strategies to decrease intracellular polyamine levels have been studied for their efficacy in reducing colorectal cancer (CRC) risk. A successful strategy combined agents that decreased polyamine synthesis by inhibiting ornithine decarboxylase with difluoromethylornithine (DFMO), and increased cellular export of polyamines by activating the spermidine ...
Christina M, Laukaitis, Eugene W, Gerner
openaire +2 more sources
The effects of DFMO on polyamine metabolism in the inner ear
Hearing Research, 1991 Difluoromethylornithine (DFMO) is a novel antineoplastic agent that was associated with an unexpected hearing loss in Phase II clinical trials. DFMO interferes with polyamine synthesis by inhibition of the enzyme ornithine decarboxylase (ODC). The objective of the current study was to establish a methodology to determine the effect of DFMO on polyamine
S C, Marks, D E, Mattox, R A, Casero
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Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
EMBO Molecular Medicine, 2023 Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and
Tracy Murray Stewart +8 more
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Frontiers in Cellular and Infection Microbiology, 2020 Current treatments of hepatitis B virus (HBV) are limited to Interferon-alpha or the nucleos(t)ide analogs antiviral therapies, and it is crucial to develop and define new antiviral drugs to cure HBV.
Binli Mao +7 more
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The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. [PDF]
PLoS ONE, 2012 Exposure to uncontrolled irradiation in a radiologic terrorism scenario, a natural disaster or a nuclear battlefield, will likely be concomitantly superimposed on other types of injury, such as trauma.
Susanna Rosi +5 more
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