Results 31 to 40 of about 47,051 (228)
Polyamine Homeostasis in Snyder-Robinson Syndrome
Medical Sciences, 2018 Loss-of-function mutations of the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech abnormalities, kyphoscoliosis, and seizures ...
Tracy Murray-Stewart +4 more
doaj +1 more source
Biomedicines, 2022 In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has been
Manuela Cervelli +10 more
doaj +1 more source
, 2008 We have investigated the energetics of DNA condensation by multivalent polyamine cations. Solution small angle x-ray scattering was used to monitor interactions between short 25 base pair dsDNA strands in the free supernatant DNA phase that coexists with
Andresen, Kurt +4 more
core +1 more source
Synapse elimination and learning rules co-regulated by MHC class I H2-Db. [PDF]
, 2014 The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Adelson, Jaimie +7 more
core +3 more sources
Animal Nutrition, 2017 Oxidative stress can damage cellular antioxidant defense and reduce livestock production efficiency. Spermine is a ubiquitous cellular component that plays important roles in stabilizing nucleic acids, modulating cell growth and differentiation, and ...
Xianjian Wu +8 more
doaj +1 more source
Detecting degree symmetries in networks [PDF]
, 2006 The surrounding of a vertex in a network can be more or less symmetric. We derive measures of a specific kind of symmetry of a vertex which we call degree symmetry -- the property that many paths going out from a vertex have overlapping degree sequences.
Petter Holme +4 more
core +2 more sources
Inter-filament Attractions Narrow the Length Distribution of Actin Filaments
, 2004 We show that the exponential length distribution that is typical of actin filaments under physiological conditions dramatically narrows in the presence of (i) crosslinker proteins (ii) polyvalent counterions or (iii) depletion mediated attractions.
Biron, David +3 more
core +1 more source
, 2004 Upon the addition of multivalent cations, a giant DNA chain exhibits a large discrete transition from an elongated coil into a folded compact state. We performed single-chain observation of long DNAs in the presence of a tetravalent cation (spermine), at
Dean J. A. +11 more
core +1 more source
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases [PDF]
Amino Acids, 2009 N-alkylated polyamine analogues have potential as anticancer and antiparasitic drugs. However, their metabolism in the host has remained incompletely defined thus potentially limiting their utility. Here, we have studied the degradation of three different spermine analogues N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine (DESPM), N-(3-benzyl ...
Merja R, Häkkinen +7 more
openaire +2 more sources
Data in Brief, 2018 Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly emerging bacteria causing infection, which has developed resistance to most of the beta-lactam antibiotics because of newly acquired low-affinity penicillin binding protein (PBP2a), which ...
Shrikant Pawar, Xiangyu Yao, ChungDar Lu
doaj +1 more source