Results 51 to 60 of about 41,546 (228)
A Highly Selective Turn-On Biosensor for Measuring Spermine/Spermidine in Human Urine and Blood.
ACS Applied Bio Materials, 2019 Spermine and spermidine serve as the key biomarkers for early-stage cancer diagnosis. This work reports a rapid, highly selective, and noninvasive sensing platform for spermine/spermidine.
Ratish R. Nair +5 more
semanticscholar +1 more source
Pharmaceutics, 2011 Gene silencing by siRNA (synthetic dsRNA of 21-25 nucleotides) is a well established biological tool in gene expression studies and has a promising therapeutic potential for difficult-to-treat diseases.
Charareh Pourzand +2 more
doaj +1 more source
Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults
Biomedicines, 2023 Early diagnosis and therapeutic intervention improve the quality of life and prognosis of patients with sarcopenia. The natural polyamines spermine and spermidine are involved in many physiological activities.
Hidenori Sanayama +8 more
doaj +1 more source
Lack of Influence of Spermine or Diet on Calf Spermine Oxidase Formation
Journal of Dairy Science, 1965 Abstract Studies were conducted to ascertain the changes in blood plasma spermine oxidase activity in the young dairy calf as the animal developed. Results show that there is a steady increase in plasma spermine oxidase activity up until 40-60 days of age with no further increase.
E, UEYAMA, C L, DAVIS, M J, WOLIN
openaire +2 more sources
Nature Communications, 2017 Polyamines are tightly regulated polycations that are essential for life. Loss-of-function mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme, cause Snyder-Robinson syndrome (SRS), an X-linked intellectual disability syndrome; however,
Chong Li +15 more
semanticscholar +1 more source
Spermine and L-name pretreatment effects on polyamine and nitric oxide metabolism in rat brain during seizures [PDF]
Journal of Medical Biochemistry, 2007 In the CNS polyamines can exert opposite effects, depending on the concentration and conditions in the cell. Protective or neurotoxic polyamine effects were documented during seizures and repeated CNS excitation.
Stojanović Ivana +4 more
doaj
Cell Reports, 2021 Summary: Hosts recognize cytosolic microbial infection via the nucleotide-binding domain-like receptor (NLR) protein family, triggering inflammasome complex assembly to provoke pyroptosis or cytokine-related caspase-1-dependent antimicrobial responses ...
Jiatiao Jiang +5 more
doaj +1 more source
浙江大学学报. 农业与生命科学版, 2019 To investigate the effects of spermine on goose immune organ indexes and expression levels of genes related to immune factors, the Sichuan adult white geese (female) were intragastrically administered with 5 and 10 mg spermine per kilogram body mass, and
YI Zhixin +7 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang +3 more
wiley +1 more source
Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene [PDF]
Human Molecular Genetics, 1998 Two mouse mutations gyro (Gy) and hypophosphatemia (Hyp) are mouse models for X-linked hypophosphatemic rickets and have been shown to be deleted for the 5' and 3' end of the mouse homolog of PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome; formerly called PEX), respectively.
B, Lorenz +9 more
openaire +2 more sources