Results 41 to 50 of about 34,064 (250)

Polyamine Homeostasis in Snyder-Robinson Syndrome

Medical Sciences, 2018
Loss-of-function mutations of the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech abnormalities, kyphoscoliosis, and seizures ...
Tracy Murray-Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero   +4 more
doaj   +1 more source

The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration

Biomedicines, 2022
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has been
Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto, Manuela Marcoli   +10 more
doaj   +1 more source

N1-dansyl-spermine: a potent polyamine antagonist.

, 2004
The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine (100 ?g, i.c.v.) resulted in ...
RYDER, SHEILA
core   +1 more source

Spermine binding to liver mitochondria

, 1996
Non-equilibrium binding of spermine to mitochondrial membranes is studied in rat liver mitochondria by applying a new thermodynamic treatment of ligand-receptor interactions (Di Note, V., Dalla Via, L., Toninello, A. and Vidali, M.
DAGMAR SILIPRANDI, DI NOTO, VITO, DALLA VIA, LISA, TONINELLO, ANTONIO, Vito Di Noto, Lisa Dalla Via, Antonio Toninello, Siliprandi Dagmar   +7 more
core   +2 more sources

Regulatory Effect of Spermine on Growth and Antioxidant System in Tomato Seedlings Grown in the Presence of Cadmium [PDF]

Journal of Stress Physiology & Biochemistry, 2019
The protective role of exogenous supplied polyamines such as spermine in detoxifying the cadmium induced toxicity was studied in the tomato plants Solanum lycopersicum, we applied a dose of (1 mM) spermine with cadmium (0, 20 and 100 µM) for 7 days.
Dorra El Gueder, Rihab Ben Fattoum, Mohamed Debouba, Ahlem Ben Khedher, Houda Gouia, Chiraz Haouari Chaffei   +5 more
doaj  

Effects of spermine on the antioxidant status and gene expression of antioxidant-related signaling molecules in the liver and longissimus dorsi of piglets

Animal, 2018
Previous studies showed that spermine could protect the organism from oxidative damage in vivo. However, in vivo information on the antioxidant-related underlying molecular mechanism of spermine is limited.
T. Fang, J. Zheng, W. Cao, G. Jia, H. Zhao, X. Chen, J. Cai, J. Wang, G. Liu   +8 more
doaj   +1 more source

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

Redox Biology, 2020
Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor ...
Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei   +12 more
doaj   +1 more source

Nap-spermine, an agonist of spermine receptor TAAR348, induced responses virtually identical to those induced by spermine.

, 2019
(A) Nap-spermine induced cAMP production in a concentration-dependent manner in TAAR348-expressing HEK293T cells (mean ± SEM, n = 5). The cAMP assay was done as in Fig 3B. (Inset) Structure of nap-spermine. (B) EOG responses to 10−7 M spermine and 10−7 M
Edmund Ellsworth (6934163), Richard R. Neubig (234327), Thomas Dexheimer (6191585), Jianfeng Ren (3277365), Yao Zu (6934166), Ke Li (106849), Yu-Wen Chung-Davidson (1688224), Liang Jia (212225), Qinghua Zhang (145923), Zhe Zhang (81603), Weiming Li (126966), Anne M. Scott (4371052)   +11 more
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

The function of spermine [PDF]

IUBMB Life, 2014
Polyamines play important roles in cell physiology including effects on the structure of cellular macromolecules, gene expression, protein function, nucleic acid and protein synthesis, regulation of ion channels, and providing protection from oxidative damage.
openaire   +3 more sources