Results 101 to 110 of about 52,673 (252)

Spermidine enhances steroidogenesis by elevating eIF5Ahyp level in hierarchical follicular granulosa cells of the goose

open access: yesPoultry Science
Imbalanced steroid hormone levels in female poultry can impair follicular development, thereby adversely affecting reproductive performance. Spermidine is reported to be involved in regulation of female reproduction and can provide aminobutyl as the only
Dongmei Jiang   +9 more
doaj   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray   +16 more
wiley   +1 more source

Mutagenic Properties of Nitrosated Spermidine

open access: yesExperimental Biology and Medicine, 1978
SummaryThe nitrosation of spermidine results in direct-acting mutagens as shown by the Ames assay utilizing S. typhimurium TA1535. The mutagenic effect is catalyzed by thiocyanate and inhibited by ascorbic acid.The reaction takes place at pH ranges 3.0-6.0. The possibility that this reaction may play a role in human gastric cancer etiology is discussed.
M G, Kokatnur, M L, Murray, P, Correa
openaire   +2 more sources

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

open access: yesVIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng   +3 more
wiley   +1 more source

Spermidine reduces cancer-related mortality in humans

open access: yes, 2019
A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality.
Kepp, Oliver   +11 more
core   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun   +6 more
wiley   +1 more source

Spermidine biosynthesis and transport modulate pneumococcal autolysis

open access: yes, 2014
Published ahead of print 4 August 2014Polyamines are small cationic molecules that have far-reaching roles in biology. In the case of pathogenic bacteria, these functions include those central to their pathogenesis.
Potter, A., Paton, J.
core   +1 more source

Neuroprotective Effects of Biosynthetic d‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen   +6 more
wiley   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du   +7 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone   +15 more
wiley   +1 more source

Home - About - Disclaimer - Privacy