Results 101 to 110 of about 57,007 (201)

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Spermidine biosynthesis by hypervirulent Francisella tularensis promotes fitness and salvages adenine

Journal of Bacteriology
Francisella tularensis is a highly infectious Tier 1 select agent that causes tularemia, a potentially fatal disease. F. tularensis subspecies tularensis (type A), including subtypes A.I and A.II, and subspecies holarctica (type B) differ considerably in
Yinshi Yue, Dhananjay Shinde, Robert Moore, Yangsheng Yu, Vinai Chittezham Thomas, Tomáš Helikar, Marilynn A. Larson   +6 more
doaj   +1 more source

Cardioprotection and lifespan extension by the natural polyamine spermidine [PDF]

, 2016
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and ...
Kiechl, Stefan, Knittelfelder, O., Eisenberg, T., Magnes, Christoph, Sedej, Simon, Büttner, Sabrina,, Alexandros Rahn, Christopher Dammbrueck, Harger, A., Hrabě de Angelis, M., Patrick Rockenfeller, Knittelfelder, Oskar, Mayr, Manuel, Pechlaner, Raimund, Stekovic, S., Dammbrueck, C., Pieber, T.R., Simonini, C., Wolfgang A Linke, Schroeder, Sabrina, de Angelis, Martin Hrabe, Dengjel, Joern, Carmona Gutierrez, Didac, Didac Carmona-Gutierrez, Dengjel, J., Horsch, Marion, Rathkolb, B., Kirsch, Alexander, Tobias Eisenberg, Kroemer, G., Viktoria Herbst, Frauke Neff, Alexander Kirsch, Mahmoud Abdellatif, Oskar Knittelfelder, Beckers, Johannes, Jan Rozman, Moustafa, T., Haemmerle, G., Johann Willeit, Sigrist, Stephan J, Johannes Beckers, Peter Willeit, Manuel Mayr, Schrepfer, Emilie, Neff, F., Narath, Sophie, Kristin Moreth, Gross, Angelina S., Horsch, M., Slaven Stekovic, Zimmermann, Andreas, Janik, Dirk, Meinitzer, Andreas, Muehlfeld, Christian, Linke, Wolfgang A, Ruckenstuhl, C., Alexandra Harger, Hu, Z., Andreas Meinitzer, Kroemer, Guido, Pendl, T., Willeit, P., Rahn, A., Kirsch, A., Tobias Pendl, Burkert Pieske, Schmidt, A., Albrecht Schmidt, Guenter Haemmerle, Simonini, Corinna, Emilie Schrepfer, Birgit Rathkolb, Pendl, Tobias, Harger, Alexandra, SCHREPFER, EMILIE Raymonde Marie, Abdellatif, M., Fuchs, Helmut, Narath, S., Schrepfer, E., Primessnig, Uwe, Willeit, Peter, Schipke, J., Moreth, Kristin, Valerie Gailus-Durner, Junichi Sadoshima, Gailus-Durner, Valerie, Sophie Narath, Büttner, S., Moreth, K., Neff, Frauke, Frank Madeo, Schroeder, S., Meinitzer, A., Pietrocola, F., Trausinger, Gert, Herbst, Viktoria, Magnes, C., Primessnig, U., Eisenberg, Tobias, von Frieling-Salewsky, Marion, Christoph Magnes, Tong, Mingming, Rahn, Alexandros, Stekovic, Slaven, Sadoshima, J., Mayr, M., Trausinger, G., Rockenfeller, Patrick, Madeo, F., Carmona-Gutierrez, Didac, Willeit, J., Hrabe de Angelis, Martin, Scorrano, L., Sigrist, Stephan J., Mingming Tong, Janik, D., Tarek Moustafa, Linke, W.A., Rathkolb, Birgit, Stephan J Sigrist, Tong, M., Eller, Kathrin, Zehan Hu, Rozman, J., Rozman, Jan, Angelina S Gross, Fuchs, H., Gert Trausinger, Stefan Kiechl, MADEO, FRANK PAUL FRANCESCO, Christoph Ruckenstuhl, Gailus Durner, Valerie, Dirk Janik, Martin Hrabe de Angelis, Gailus-Durner, V., Kiechl, S., Corinna Simonini, Pechlaner, R., Sedej, S., Madeo, Frank, Dammbrueck, Christopher, Ruckenstuhl, Christoph, Pieske, B., Helmut Fuchs, Sabrina Büttner, Sigrist, S.J., Christian Mühlfeld, Marion von Frieling-Salewsky, Linke, Wolfgang A., Hu, Zehan, Zimmermann, A., Joern Dengjel, Carmona-Gutierrez, D., Beckers, J., Pieber, Thomas, Simon Sedej, Willeit, Johann, Sabrina Schroeder, Pietrocola, Federico, Haemmerle, Guenter, Federico Pietrocola, Schmidt, Albrecht, Uwe Primessnig, Luca Scorrano, Abdellatif, Mahmoud, Sadoshima, Junichi, Andreas Zimmermann, Julia Schipke, Eller, K., Marion Horsch, Thomas Pieber, Moustafa, Tarek, Raimund Pechlaner, von Frieling-Salewsky, M., Gross, Angelina S, Gross, A.S., Mühlfeld, C., Schipke, Julia, Kathrin Eller, Rockenfeller, P., von Frieling Salewsky, Marion, Pieske, Burkert, Guido Kroemer, Herbst, V., Madeo, Frank F., Dengjel, Jörn, Eisenberg, T. ; Abdellatif, M. ; Schroeder, S. ; Primessnig, U. ; Stekovic, S. ; Pendl, T. ; Harger, A. ; Schipke, J. ; Zimmermann, A. ; Schmidt, A. ; Tong, M. ; Ruckenstuhl, C. ; Dammbrueck, C. ; Gross, A.S. ; Herbst, V. ; Magnes, C. ; Trausinger, G. ; Narath, S. ; Meinitzer, A. ; Hu, Z. ; Kirsch, A. ; Eller, K. ; Carmona-Gutierrez, D. ; Büttner, S. ; Pietrocola, F. ; Knittelfelder, O. ; Schrepfer, E. ; Rockenfeller, P. ; Simonini, C. ; Rahn, A. ; Horsch, M. ; Moreth, K. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Neff, F. ; Janik, D. ; Rathkolb, B. ; Rozman, J. ; Hrabé de Angelis, M. ; Moustafa, T. ; Haemmerle, G. ; Mayr, M. ; Willeit, P. ; von Frieling-Salewsky, M. ; Pieske, B. ; Scorrano, L. ; Pieber, T.R. ; Pechlaner, R. ; Willeit, J. ; Sigrist, S.J. ; Linke, W.A. ; Mühlfeld, C. ; Sadoshima, J. ; Dengjel, J. ; Kiechl, S. ; Kroemer, G. ; Sedej, S. ; Madeo, F., Scorrano, Luca, Mühlfeld, Christian, Büttner, Sabrina   +190 more
core   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Effect of Spermidine on Endothelial Function in Systemic Lupus Erythematosus Mice [PDF]

© 2024 by the authors. cc-byEndothelial dysfunction is common in Systemic Lupus Erythematosus (SLE), even in the absence of cardiovascular disease. Evidence suggests that impaired mitophagy contributes to SLE. Mitochondrial dysfunction is also associated
Hyoseon Kim, Massett, Michael P., Michael P. Massett, Kim, Hyoseon   +3 more
core   +1 more source

DNA mesophases induced by spermidine: Structural properties and biological implications

, 1996
Conditions of formation of DNA aggregates by the addition of spermidine were determined with 146 base pair DNA fragments as a function of spermidine and NaCl concentration.
Pelta, Juan, Doucet, Jean, Livolant, Françoise, Durand, Dominique   +3 more
core   +1 more source

Duckweeds under salt stress: a meta‐analysis of growth inhibition in relation to morphological and physiological traits and a systematic review of molecular responses

New Phytologist, EarlyView.
Salinity reduces duckweed growth responses. Summary Salinity is one of the main environmental factors limiting the performance of duckweeds and despite growing ecological and biotechnological interest in these macrophytes, there is a lack of quantitative analyses of their responses to sodium chloride.
Saimon Branco Bueno, Alice Pita‐Barbosa, Ana Paula Roschildt, Daniel Burd Villanova, Janaina Cardozo de Mello, Alex Lindor, Tanise Luísa Sausen, Junior Borella   +7 more
wiley   +1 more source

Characterization of spermidine binding to solubilized plasma membrane proteins from zucchini hypocotyls

, 1998
In this work [14C]spermidine binding to total proteins solubilized from plasma membrane purified from zucchini (Cucurbita pepo I.) hypocotyls was investigated. Proteins were solubilized using octyl glucosidc as a detergent. Specific polyamine binding was
Battistini M. L., Tassoni A., Bagni N., Antognoni F., Sanvido O., Fabiana Antognoni, Maria Luisa Battistini, Annalisa Tassoni, Olivier Sanvido, Nello Bagni   +9 more
core   +1 more source

Perturbation of Spermine Homoeostasis Uncouples Hypersensitive Cell Death From Systemic Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Polyamines are key regulators of plant stress responses, yet their contribution to coordinating local immune responses with systemic immunity remains poorly understood. Here, we investigated how spermine (Spm) homeostasis influences local and systemic defence responses in Arabidopsis thaliana following inoculation with Pseudomonas syringae pv.
Jiaqi Zhao, Kostadin E. Atanasov, Olga Jauregui, Rubén Alcázar   +3 more
wiley   +1 more source

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Experimental and Molecular Medicine, 2018
Aging: toward a natural treatment for osteoarthritis The naturally occurring small molecule spermidine might prevent and repair the cartilage damage in osteoarthritis, commonly associated with aging.
Pradeep K. Sacitharan, Seint Lwin, George Bou Gharios, James R. Edwards   +3 more
doaj   +1 more source