Results 121 to 130 of about 57,007 (201)
PlateletsMetabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins ...
Xing Liu +11 more
doaj +1 more source
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production
Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3152-3164, November 2026.ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise +3 more
wiley +1 more source
Crystallization of spermidine synthase for structure-based inhibitory drug design.
Spermidine, putrescine and spermine are essential polyamines found in all living organisms. Putrescine, synthesized from L-ornithine, which is a non-essential amino acid in humans, serves as the precursor.
Canfield, Molly.
core
MedComm, Volume 7, Issue 11, November 2026.Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen +3 more
wiley +1 more source
Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
Scientific ReportsThe expression of ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and its post-translational modification (ISGylation) are significantly activated by interferons or pathogen infections, highlighting their roles in innate immune ...
Haruka Etori +3 more
doaj +1 more source
, 2011 The ability of α-, ν-, γ- and ω-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated.
Madhubala, R. +9 more
core +1 more source
Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective
VIEW Medicine, Volume 1, Issue 1, November 2026.Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng +3 more
wiley +1 more source
Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis
Immunology, Volume 179, Issue 3, Page 418-433, November 2026.Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao +16 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.Die gezielte Veränderung der Erkennungsumgebung am Portal von Cucurbit[7]uril (CB7) wandelt einen Wirt ohne intrinsisches optisches Signal in einen motivselektiven photolumineszenten Rezeptor um. Das am Portal vororganisierte CB7‐Rubpy‐Konjugat zeigt Änderungen der Zugänglichkeit aromatischer Motive unmittelbar an und ermöglicht dadurch die optische ...
Patrick Gruhs +10 more
wiley +1 more source