Activation of Endoplasmic Reticulum Stress Response by Enhanced Polyamine Catabolism Is Important in the Mediation of Cisplatin-Induced Acute Kidney Injury [PDF]
PLoS ONE, 2017 Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with ...
Robert A Casero +2 more
exaly +5 more sources
Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment [PDF]
BiomedicinesCisplatin, a chemotherapeutic agent, can cause nephrotoxic and ototoxic injuries. Using a mouse model of repeated low dose cisplatin (RLDC), we compared the kidneys of cisplatin- and vehicle-treated mice on days 3 (early injury phase) and 35 (late injury/
Robert A Casero +2 more
exaly +5 more sources
Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype [PDF]
Cells, 2018 Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment.
Olga N. Ivanova +11 more
doaj +5 more sources
L-Aminoguanidine Induces Imbalance of ROS/RNS Homeostasis and Polyamine Catabolism of Tomato Roots after Short-Term Salt Exposure [PDF]
Antioxidants, 2023 Polyamine (PA) catabolism mediated by amine oxidases is an important process involved in fine-tuning PA homeostasis and related mechanisms during salt stress.
Ágnes Szepesi +12 more
doaj +4 more sources
Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role due to Low Expression [PDF]
CellsBiogenic polyamines are ubiquitous compounds. Dysregulation of their metabolism is associated with the development of various pathologies, including cancer, hyperproliferative diseases, and infections.
Olga N. Ivanova +14 more
doaj +3 more sources
Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation [PDF]
Biomolecules, 2021 Background: In the brain, polyamines are mainly synthesized in neurons, but preferentially accumulated in astrocytes, and are proposed to be involved in neurodegenerative/neuroinflammatory disorders and neuron injury.
Chiara Cervetto +11 more
doaj +2 more sources
Polyamine Catabolism in Plants: A Universal Process With Diverse Functions [PDF]
Frontiers in Plant Science, 2019 Polyamine (PA) catabolic processes are performed by copper-containing amine oxidases (CuAOs) and flavin-containing PA oxidases (PAOs). So far, several CuAOs and PAOs have been identified in many plant species.
Wei Wang +4 more
doaj +2 more sources
Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
doaj +2 more sources
Polyamine Metabolism in Brain Health and Disease [PDF]
Neuropharmacology and TherapyPolyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao +2 more
doaj +2 more sources
Polyamine metabolism in ischemia reperfusion injury: common mitochondrial mechanisms and organ-specific differences [PDF]
Journal of Translational MedicinePolyamines are essential polycations that play pivotal roles in various cellular processes, including cell proliferation, redox regulation, protein synthesis, and particularly the maintenance of mitochondrial function. During ischemia/reperfusion injury (
Yangqi Chu +5 more
doaj +2 more sources