Results 41 to 50 of about 57,622 (148)

POLYAMINE OXIDATION-ASSOCIATED DAMAGE: FRIEND OR FOE? IMPLICATIONS FOR POLYAMINE THERAPEUTIC INTERVENTIONS [PDF]

, 2021
Polyamines are polycationic alkylamines involved in many cellular functions, and as a result their homeostasis is tightly regulated through coordinated biosynthesis, catabolism, and transport. The oxidation of polyamines occurs during their catabolism as
Holbert, Cassandra
core  

Transcriptional Modulation of Polyamine Metabolism in Fruit Species Under Abiotic and Biotic Stress

Frontiers in Plant Science, 2019
Polyamines are growth regulators that have been widely implicated in abiotic and biotic stresses. They are also associated with fruit set, ripening, and regulation of fruit quality-related traits.
Ana Margarida Fortes, Patricia Agudelo-Romero, Patricia Agudelo-Romero, Patricia Agudelo-Romero, Diana Pimentel, Noam Alkan   +5 more
doaj   +1 more source

Molecular Cloning, Subcellular Localization, and Abiotic Stress Induction Analysis of a Polyamine Oxidase Gene from Oryza sativa

International Journal of Agronomy, 2023
Abiotic stress is a major bottleneck for crop productivity. To counter abiotic stresses, plants have developed several strategies, and the accumulation of polyamine (PA) serving as an osmolyte is one of them.
Ishita Samanta, Shweta Chaturvedi, Pamela Chanda Roy, Gopal Chowdhary   +3 more
doaj   +1 more source

Genome-Wide Identification and Functional Analysis of Polyamine Oxidase Genes in Maize Reveal Essential Roles in Abiotic Stress Tolerance

Frontiers in Plant Science, 2022
Polyamines (PAs) play a critical role in growth and developmental processes and stress responses in plants. Polyamine oxidase (PAO) is a flavin adenine dinucleotide (FAD)-dependent enzyme that plays a major role in PA catabolism. Here, for the first time,
Yan Xi, Wenjing Hu, Yue Zhou, Xiang Liu, Yexiong Qian   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes

Biomolecules, 2022
Epilepsy is one of the most common neurological disorders and severely impacts the life quality of patients. Polyamines are ubiquitous, positively charged aliphatic amines that are present at a relatively high level and help regulate the maintenance of ...
Jiayu Liu, Zhi Yu, Buajieerguli Maimaiti, Qian Meng, Hongmei Meng   +4 more
doaj   +1 more source

Determination of di-/Polyamine Oxidase Activity in Plants by an In-Gel Spermidine Oxidation Assay

, 2018
Diamine and polyamine catabolism controls plant development, resistance to pathogens and stress responses. Diamine and polyamine oxidases control the catabolism of diamines and polyamines, respectively. Two major routes of di-/polyamine catabolism exist:
Sveriges lantbruksuniversitet., Moschou, Panagiotis Nikolaou,   +1 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Opposing Roles for ATP13A2 and ATP13A3 in Breast Cancer Subtype-Specific Polyamine Homeostasis

Biomolecules
Polyamine homeostasis is essential for normal cellular function and is maintained through coordinated regulation of polyamine biosynthesis, catabolism, and transport.
Emily Meeus, Jan Eggermont, Sarah van Veen, Peter Vangheluwe   +3 more
doaj   +1 more source