Results 21 to 30 of about 57,622 (148)

Apigenin Inhibits Human SW620 Cell Growth by Targeting Polyamine Catabolism. [PDF]

Evid Based Complement Alternat Med, 2017
Apigenin is a nonmutagenic flavonoid that has antitumor properties. Polyamines are ubiquitous cellular polycations, which play an important role in the proliferation and differentiation of cancer cells.
Wang J, Li T, Zang L, Pan X, Wang S, Wu Y, Wang G.   +6 more
europepmc   +2 more sources

SAT1-Induced Spermidine Depletion Potentiates Food Allergy. [PDF]

Adv Sci (Weinh)
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Liu M, Zhang B, Wang J, Jiang Y, Han S, Wang Q, Zeng L, Wang J, Che H.   +8 more
europepmc   +2 more sources

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features. [PDF]

Allergy, 2018
Background Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored.
Jain V, Raina S, Gheware AP, Singh R, Rehman R, Negi V, Murray Stewart T, Mabalirajan U, Mishra AK, Casero RA, Agrawal A, Ghosh B.   +11 more
europepmc   +2 more sources

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Journal of Neuroinflammation, 2020
Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored.
Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani   +14 more
doaj   +1 more source

Genome-Wide Identification and Characterization of the Polyamine Uptake Transporter (Put) Gene Family in Tomatoes and the Role of Put2 in Response to Salt Stress

Antioxidants, 2023
The polyamine uptake transporter (Put), an important polyamines-related protein, is involved in plant cell growth, developmental processes, and abiotic stimuli, but no research on the Put family has been carried out in the tomato.
Min Zhong, Lingqi Yue, Wei Liu, Hongyi Qin, Bingfu Lei, Riming Huang, Xian Yang, Yunyan Kang   +7 more
doaj   +1 more source

Pseudomonas fluorescens DN16 Enhances Cucumber Defense Responses Against the Necrotrophic Pathogen Botrytis cinerea by Regulating Thermospermine Catabolism

Frontiers in Plant Science, 2021
Plants can naturally interact with beneficial rhizobacteria to mediate defense responses against foliar pathogen infection. However, the mechanisms of rhizobacteria-mediated defense enhancement remain rarely clear.
Lin Zhu, Nana Qian, Yujun Sun, Yujun Sun, Xiaoming Lu, Haiming Duan, Lisheng Qian, Lisheng Qian   +7 more
doaj   +1 more source

Mechanisms of polyamine catabolism-induced acute pancreatitis [PDF]

, 2007
Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the tissues in the mammalian body, pancreas has the highest concentration of the natural polyamine ...
Merentie, M., M Merentie, Keinänen, T. A., J Jänne, A Uimari, L Alhonen, T A Keinänen, Jänne, J., M T Hyvönen, Hyvönen, M. T., Alhonen, L., Uimari, Anne   +11 more
core   +1 more source

Modulation of polyamine catabolism in pea seedlings by calcium during salinity stress

Plant Protection Science, 2012
The relation of polyamine catabolism in the response of Pisum sativum to salinity stress was investigated. Pea seedlings were grown in increasing concentrations of Na+ or K+ or at different concentration ratios of these ions. We studied the effect of Ca2+
Jana Piterková, Lenka Luhová, Ludmila Zajoncová, Marek Šebela, Marek Petřivalský   +4 more
doaj   +1 more source

T_H17-Associated Polyamine Metabolism-Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis. [PDF]

Adv Sci (Weinh)
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Zhu C, Li T, Jin Y, Li Y, Liu Q, Fang R, Qu L, Tang X, Li R, Zhao X, Hao J, Fang B, Xia L.   +12 more
europepmc   +2 more sources

Catabolism as a mechanism of polyamine detoxification

, 1998
Maintenance of optimal polyamine pool levels is critical for cell survival. Intracellular polyamine depletion is usually cytostatic, whereas unregulated polyamine accumulation can result in cytotoxicity.
Lawson, Kathryn René
core   +3 more sources