Results 31 to 40 of about 57,622 (148)
Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma
Frontiers in Oncology, 2012 Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble +8 more
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Medical Sciences, 2022 The polyamines spermidine and spermine are positively charged aliphatic molecules. They are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein and nucleic acid interactions, oxidative balance, and cell ...
Kamyar Zahedi +2 more
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Polyamine Oxidases Play Various Roles in Plant Development and Abiotic Stress Tolerance
Plants, 2019 Polyamines not only play roles in plant growth and development, but also adapt to environmental stresses. Polyamines can be oxidized by copper-containing diamine oxidases (CuAOs) and flavin-containing polyamine oxidases (PAOs). Two types of PAOs exist in
Zhen Yu, Dongyu Jia, Taibo Liu
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Differential regulation of root arginine catabolism and polyamine metabolism in clubroot-susceptible and partially resistant Arabidopsis genotypes [PDF]
, 2008 The hypertrophy and hyperplasia of infected roots into clubs are the intrinsic characteristics of clubroot, one of the economically most important diseases in Brassica crops worldwide.
Jubault, Mélanie +8 more
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Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities
Bio-Protocol, 2014 The polyamines, spermidine (Spd) and spermine, and their diamine precursor putrescine, are important regulators of various cellular functions, such as proliferation and differentiation.
Mervi Hyvönen +2 more
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Polyamine Metabolism in Disease and Polyamine-Targeted Therapies [PDF]
, 2019 Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis ...
Murray-Stewart, Tracy
core +1 more source
Biomolecules, 2023 Reactive oxygen species (ROS) play a major role in the regulation of various processes in the cell. The increase in their production is a factor contributing to the development of numerous pathologies, including inflammation, fibrosis, and cancer ...
Olga N. Ivanova +10 more
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Antioxidants, 2022 Metabolism and regulation of cellular polyamine levels are crucial for living cells to maintain their homeostasis and function. Polyamine oxidases (PAOs) terminally catabolize polyamines or catalyse the back-conversion reactions when spermine is ...
Péter Benkő +2 more
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Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication
Cell Reports, 2019 Summary: Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and ...
Patrick M. Tate +2 more
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Molecules, 2022 Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells.
Ekaterina V. Neborak +10 more
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