Results 51 to 60 of about 57,622 (148)

Discovery and antitumor evaluation of novel inhibitors of spermine oxidase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise.
Lidan Sun, Jianlin Yang, Yu Qin, Yanlin Wang, Hongyan Wu, You Zhou, Chunyu Cao   +6 more
doaj   +1 more source

Arginine Catabolism and Polyamine Biosynthesis Pathway Disparities Within Francisella tularensis Subpopulations

Frontiers in Microbiology, 2022
Francisella tularensis is a highly infectious zoonotic pathogen with as few as 10 organisms causing tularemia, a disease that is fatal if untreated. Although F. tularensis subspecies tularensis (type A) and subspecies holarctica (type B) share over 99.5%
Yinshi Yue, Bhanwar Lal Puniya, Tomáš Helikar, Benjamin Girardo, Steven H. Hinrichs, Marilynn A. Larson   +5 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Polyamine biosynthesis inhibitors combined with systemic hyperthermia in cancer therapy [PDF]

, 1990
A Phase I clinical trial has been initiated at the University of Arizona Cancer Center which combines escalating oral doses of the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO), with systemic hyperthermia (approximately 41.5 ...
Harari, Paul M, Fuller, David JM, Shimm, David S, Gerner, Eugene W, Carper, Stephen W, Meyskens, Frank L, Croghan, Marilyn K, David S. Shimm, Frank L. Meyskens, Paul M. Harari, David J.M. Fuller, Marilyn K. Croghan, Eugene W. Gerner, Stephen W. Carper   +13 more
core   +1 more source

Pattern and concentration of free and acetylated polyamines in urine of cirrhotic patients

The International Journal of Biological Markers, 1992
The pattern and concentration of urinary, free, monoacetylated and total polyamines were determined in 31 cirrhotic patients, divided into three classes according to Child's classification, and in 28 healthy subjects.
L. Cecco, S. Antoniello, M. Auletta, M. Cerra, P. Bonelli   +4 more
doaj   +1 more source

Defining novel plant polyamine oxidase subfamilies through molecular modeling and sequence analysis

BMC Evolutionary Biology, 2019
Background The polyamine oxidases (PAOs) catabolize the oxidative deamination of the polyamines (PAs) spermine (Spm) and spermidine (Spd). Most of the phylogenetic studies performed to analyze the plant PAO family took into account only a limited number ...
Cesar Daniel Bordenave, Carolina Granados Mendoza, Juan Francisco Jiménez Bremont, Andrés Gárriz, Andrés Alberto Rodríguez   +4 more
doaj   +1 more source

GmPAO-mediated polyamine catabolism enhances soybean Phytophthora resistance without growth penalty

Phytopathology Research, 2022
Plant immunity is activated upon perception of pathogens and often affects growth when it is constitutively active. It is still a challenge to balance plant immunity and growth in disease resistance breeding.
Kun Yang, Qiang Yan, Yi Wang, Hao Peng, Maofeng Jing, Daolong Dou   +5 more
doaj   +1 more source

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Biomedicines, 2023
The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Norspermidine is not a self-produced trigger for biofilm disassembly [PDF]

, 2014
Formation of Bacillus subtilis biofilms, consisting of cells encapsulated within an extracellular matrix of exopolysaccharide and protein, requires the polyamine spermidine.
Stanley-Wall, Nicola R.; id_orcid, Hobley, Laura, Kim, Sok Ho, Stanley-Wall, Nicola R., Michael, Anthony J., Maezato, Yukari, Fairlamb, Alan H.; id_orcid, Fairlamb, Alan H., Wyllie, Susan   +8 more
core   +1 more source