Results 61 to 70 of about 57,622 (148)

Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases

Frontiers in Nutrition, 2019
The polyamines putrescine, spermidine, and spermine are widely distributed polycationic compounds essential for cellular functions. Intracellular polyamine pools are tightly regulated by a complex regulatory mechanism involving de novo biosynthesis ...
Bruno Ramos-Molina, Bruno Ramos-Molina, Maria Isabel Queipo-Ortuño, Maria Isabel Queipo-Ortuño, Ana Lambertos, Ana Lambertos, Francisco J. Tinahones, Francisco J. Tinahones, Rafael Peñafiel, Rafael Peñafiel   +9 more
doaj   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Structure and biological action of analogs and derivatives of biogenic polyamines

Тонкие химические технологии, 2021
Objectives. Biogenic polyamines are widely present in nature. They are characteristic of both protozoan cells and multicellular organisms. These compounds have a wide range of biological functions and are necessary for normal growth and development of ...
O. S. Egorov, N. Yu. Borisova, E. Ya. Borisova, M. L. Rezhabbaev, E. Yu. Afanas’eva, E. V. Arzamastsev   +5 more
doaj   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic

, 2022
Naturally occurring polyamines are absolutely required for cellular growth and proliferation. Many neoplastic cells are reliant on elevated polyamine levels and maintain these levels through dysregulated polyamine metabolism.
Foley, Jackson R., Jackson R. Foley, Holbert, Cassandra E., Casero, Robert A., Murray Stewart, Tracy, Cassandra E. Holbert, Tracy Murray Stewart, Robert A. Casero   +7 more
core   +1 more source

Characterizing a Novel Cocksackievirus B3 Protease Mutant and Its Response to Polyamine Depletion [PDF]

, 2021
Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Hulsebosch, Bridget
core   +1 more source

Extending the limits of algal growth and stress resilience – the desert alga Chlorella ohadii as an emerging model

New Phytologist, EarlyView.
Multiple facets of Chlorella ohadii biological properties and potential as a research model and biotechnology platform. Summary Since its isolation from the sand dunes of the Negev Desert over a decade ago, the unicellular green alga Chlorella ohadii has turned into a reference organism for studying photosynthesis, metabolism, and abiotic stress ...
Or Geffen, Hilla Matityahu, Iftach Yacoby, Michal Breker, Haim Treves   +4 more
wiley   +1 more source

Apoplast multi‐omics profiling during fungal infection uncovers new players of basal and early induced immunity in Arabidopsis thaliana

New Phytologist, EarlyView.
Important processes taking place in the apoplast during plant–pathogen interaction identified by multi‐omics profiling of the apoplastic fluid. Summary The extracellular space in plant tissues, known as the apoplast, remains one of the least characterized cellular compartments.
Antoine Davière, Sylvie Jolivet, Annie Auger, Gilles Clement, Stephanie Boutet, Jean Chrisologue Totozafy, Thierry Balliau, Mélisande Blein‐Nicolas, Justine Rouffet, Marie‐Christine Soulié, Mathilde Fagard   +10 more
wiley   +1 more source

Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803 [PDF]

, 2007
Schriek S, Rückert C, Staiger D, Pistorius EK, Michel K-P. Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis ...
Klaus-Peter Michel, Schriek, Sarah, Staiger Dorothee, Michel, Klaus-Peter, Rückert Christian, Schriek Sarah, Pistorius Elfriede K, Elfriede K Pistorius, Staiger, Dorothee, Sarah Schriek, Rückert, Christian ; https://orcid.org/, Michel Klaus-Peter, Pistorius, Elfriede K., Christian Rückert, Dorothee Staiger   +14 more
core   +1 more source

From isotopologues to isotopomers: advances in mass spectrometry‐based positional 13C analysis in plants

New Phytologist, EarlyView.
Workflow of gas chromatography coupled to mass spectrometry (GC‐MS)‐based 13C‐labelling analysis of plant metabolites. Summary Carbon fluxes throughout metabolic networks can be investigated experimentally through 13C‐isotope labelling experiments (13C‐ILE) and 13C‐metabolic flux analysis (13C‐MFA).
Valéria F. Lima, Jônatas G.S.B. Oliveira, Luisa Wittemeier, Joachim Kopka, Danilo M. Daloso   +4 more
wiley   +1 more source