Results 11 to 20 of about 57,622 (148)

Polyamine Catabolism in Acute Kidney Injury [PDF]

International Journal of Molecular Sciences, 2019
Acute kidney injury (AKI) refers to an abrupt decrease in kidney function. It affects approximately 7% of all hospitalized patients and almost 35% of intensive care patients. Mortality from acute kidney injury remains high, particularly in critically ill
Sharon Barone, Kamyar Zahedi, Manoocher Soleimani   +2 more
exaly   +3 more sources

Influence of a phyA Mutation on Polyamine Metabolism in Arabidopsis Depends on Light Spectral Conditions

Plants, 2023
The aim of the study was to reveal the influence of phyA mutations on polyamine metabolism in Arabidopsis under different spectral compositions. Polyamine metabolism was also provoked with exogenous spermine.
Altafur Rahman, Judit Tajti, Imre Majláth, Tibor Janda, Sylva Prerostova, Mohamed Ahres, Magda Pál   +6 more
doaj   +2 more sources

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy

Medical Sciences, 2022
Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert, Jackson R. Foley, Ao Yu, Tracy Murray Stewart, Otto Phanstiel, David Oupicky, Robert A. Casero   +6 more
doaj   +2 more sources

Inhibiting Copper Amine Oxidase Using L-Aminoguanidine Induces Cultivar and Age-Dependent Alterations of Polyamine Catabolism in Tomato Seedlings [PDF]

Agriculture, 2022
Many effects of polyamines (PAs) are well known in plant developmental processes; however, the significance of their catabolism is not well understood. Copper amine oxidase (CuAO) is involved in the degradation of diamine putrescine (Put).
Ágnes Szepesi, László Bakacsy, Henrietta Kovács, Árpád Szilágyi, Zoltán Márton Köhler   +4 more
doaj   +2 more sources

Polyamine Analog Diethylnorspermidine Restricts Coxsackievirus B3 and Is Overcome by 2A Protease Mutation In Vitro

Viruses, 2021
Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Bridget M. Hulsebosch, Bryan C. Mounce
doaj   +2 more sources

Polyamine metabolism and anti-tumor immunity [PDF]

Frontiers in Immunology
Growing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu, Yan Zeng, Yu-Yang You, Qi-Yue Chen   +3 more
doaj   +2 more sources

A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor. [PDF]

Int J Mol Sci, 2022
Krysenko S, Okoniewski N, Nentwich M, et al. A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor. International journal of molecular sciences.
Krysenko S, Okoniewski N, Nentwich M, Matthews A, Bäuerle M, Zinser A, Busche T, Kulik A, Gursch S, Kemeny A, Bera A, Wohlleben W.   +11 more
europepmc   +2 more sources

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and ...
Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini   +10 more
doaj   +2 more sources

Activation of Polyamine Catabolism Promotes Glutamine Metabolism and Creates a Targetable Vulnerability in Lung Cancer [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Wei-Xing Zong, Ning Wang, Yongbo Wang
exaly   +2 more sources

Polyamine Metabolism for Drug Intervention in Trypanosomatids [PDF]

Pathogens
Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world’s poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease and different types of
Yolanda Pérez-Pertejo, Carlos García-Estrada, María Martínez-Valladares, Sankaranarayanan Murugesan, Rosa M. Reguera, Rafael Balaña-Fouce   +5 more
doaj   +3 more sources