Results 41 to 50 of about 164,541 (160)
Journal of Applied Toxicology, EarlyView.ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
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Discovery and antitumor evaluation of novel inhibitors of spermine oxidase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise.
Lidan Sun +6 more
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Journal of Neuroinflammation, 2020 Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored.
Kamyar Zahedi +14 more
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Identification and Characterization of Novel Small-Molecule SMOX Inhibitors
Medical Sciences, 2022 The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine
Amelia B. Furbish +6 more
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Pest Management Science, EarlyView.This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti +3 more
wiley +1 more source
Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.
PLoS ONE, 2017 Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers.
Tracy Murray-Stewart +6 more
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Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus
Pest Management Science, EarlyView.Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano +7 more
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Frontiers in Plant ScienceIntroductionSugarcane endophytic nitrogen-fixing bacterium Klebsiella variícola DX120E displayed broad impact on growth, but the exact biological mechanism, especially polyamines (PAs) role, is still meager.MethodsTo reveal this relationship, the content
Ying Qin +10 more
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British Journal of Pharmacology, EarlyView.Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang +5 more
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, 1986 The paper reports a comparative study of the activity and distribution of polyamine oxidase (PAO) in carcinomatous human breast tissue and in the healthy uninvolved tissue of the same breast.
Marta Romano, Patrizia Bonelli
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