Results 41 to 50 of about 152,403 (204)
Discovery and antitumor evaluation of novel inhibitors of spermine oxidase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise.
Lidan Sun +6 more
doaj +1 more source
Medical Sciences, 2018 Polyamine levels are elevated in breast tumors compared to those of adjacent normal tissues. The female sex hormone, estrogen is implicated in the origin and progression of breast cancer.
T. J. Thomas, Thresia Thomas
doaj +1 more source
Food Bioengineering, EarlyView.Fermentation enhances nutritional & techno‐functional properties of plant protein. Three distinct stages of fermentation impact on different aspects of plant protein. Fermentation induces flavors modulation through new organic compounds formation. Plant protein fermentation improves their utility in food applications.
Disha +3 more
wiley +1 more source
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source
PLoS ONE, 2013 Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal. Spermine oxidase is highly expressed in the mouse brain and plays a key role in regulating the
Manuela Cervelli +12 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored.
Kamyar Zahedi +14 more
doaj +1 more source
Future Postharvest and Food, EarlyView.The physiological effects and molecular responses of postharvest vegetables to temperature fluctuations, and multi‐technology integration strategies for maintaining postharvest vegetable quality. ABSTRACT Vegetables are indispensable agricultural products in the human diet. With the continuous growth of vegetable production and consumption, postharvest
Shuaishuai Dai +4 more
wiley +1 more source
Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]
, 2009 Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Maurice, HB, Karodia, N, Phillips, Roger
core +3 more sources
Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.
PLoS ONE, 2017 Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers.
Tracy Murray-Stewart +6 more
doaj +1 more source
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors
Medical Sciences, 2022 The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine
Amelia B. Furbish +6 more
doaj +1 more source