Discovery and Antitumor Evaluation of Novel Inhibitors of Spermine Oxidase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Increasing knowledge of the relationship between cancer and dysregulated polyamine catabolism suggests interfering with aberrant polyamine metabolism for anticancer therapy that will have considerable clinical promise.
Yu Qin, Lidan Sun, Chunyu Cao
exaly +7 more sources
The Spermine Oxidase/Spermine Axis Coordinates ATG5‐Mediated Autophagy to Orchestrate Renal Senescence and Fibrosis [PDF]
Advanced ScienceDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Dan Luo +13 more
doaj +5 more sources
Exploring the Activity of Polyamine Analogues on Polyamine and Spermine Oxidase: Methoctramine, a Potent and Selective Inhibitor of Polyamine Oxidase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and ...
Manuela Cervelli +2 more
exaly +5 more sources
Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures [PDF]
Biomolecules, 2022 Polyamines are organic polycations ubiquitously present in living cells. Polyamines are involved in many cellular processes, and their content in mammalian cells is tightly controlled.
Manuela Marcoli +6 more
doaj +5 more sources
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study [PDF]
Scientific Reports, 2021 Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention ...
João Fadista +17 more
doaj +3 more sources
Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients [PDF]
Biomedicines, 2022 Uncovering tumor markers of colorectal cancer is important for the early detection and prognosis of the patients. Spermine oxidase (SMOX) is upregulated in various cancers.
Sooyoun Kim +11 more
doaj +5 more sources
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor [PDF]
Communications Biology, 2022 Rational engineering of human spermine oxidase yields crystallizable structures and the design of an allosteric inhibitor.
Elsie Diaz +17 more
doaj +2 more sources
Spermine Oxidase–Substrate Electrostatic Interactions: The Modulation of Enzyme Function by Neighboring Colloidal ɣ-Fe2O3 [PDF]
Biomolecules, 2023 Protein–nanoparticle hybridization can ideally lead to novel biological entities characterized by emerging properties that can sensibly differ from those of the parent components.
Graziano Rilievo +11 more
doaj +2 more sources
Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation [PDF]
Frontiers in Cell and Developmental Biology, 2023 Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis.
Clara Perrone +26 more
doaj +2 more sources
Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues. [PDF]
PLoS ONE, 2022 The enzyme spermine oxidase (SMOX) is involved in polyamine catabolism and converts spermine to spermidine. The enzymatic reaction generates reactive hydrogen peroxide and aldehydes as by-products that can damage DNA and other biomolecules.
Armand W J W Tepper +5 more
doaj +2 more sources