Results 21 to 30 of about 150,601 (174)
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm [PDF]
BMC Cancer, 2010 Background Polyamine metabolism has a critical role in cell death and proliferation representing a potential target for intervention in breast cancer (BC).
Gucciardo Giacomo +12 more
doaj +4 more sources
Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina [PDF]
International Journal of Molecular Sciences, 2022 Priya Narayanan +2 more
exaly +2 more sources
Spectroscopic and calorimetric characterization of spermine oxidase and its association forms [PDF]
Biochemical Journal, 2017 Spermine oxidase (SMOX) is a flavin-containing enzyme that oxidizes spermine to produce spermidine, 3-aminopropanaldehyde and hydrogen peroxide. SMOX has been shown to play key roles in inflammation and carcinogenesis; indeed it is differentially ...
Cervelli, Manuela +17 more
core +5 more sources
Identification of a Novel Substrate-Derived Spermine Oxidase Inhibitor. [PDF]
Acta Naturae, 2020 Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in M-mM concentrations in all eukaryotic cells, is precisely regulated by coordinated activities of the enzymes of polyamine synthesis, degradation, and transport, in order to sustain normal cell growth and viability. Spermine oxidase (SMOX) is the key and most recently
Dunston TT +7 more
europepmc +4 more sources
Dual inhibitors of LSD1 and spermine oxidase. [PDF]
Medchemcomm, 2019 Dual inhibitors of LSD1 and SMOX, with no activity against N 1 -acetylpolyamine oxidase (PAOX).
Holshouser S +8 more
europepmc +4 more sources
Biomedicines, 2023 The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj +1 more source
Biomedicines, 2022 In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has been
Manuela Cervelli +10 more
doaj +1 more source
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors
Medical Sciences, 2022 The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine
Amelia B. Furbish +6 more
doaj +1 more source
An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro. [PDF]
PLoS ONE, 2018 Amine oxidase, which participates in the metabolic processing of biogenic amines, is widely found in organisms, including higher organisms and various microorganisms.
Junguo Liu +8 more
doaj +1 more source
Frontiers in Plant Science, 2021 Alkali stress limits plant growth and yield more strongly than salt stress and can lead to the appearance of yellow leaves; however, the reasons remain unclear.
Jianhui Bai +4 more
doaj +1 more source