Results 11 to 20 of about 150,601 (174)
Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine [PDF]
Medical Sciences, 2018 Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle health and function is essential for the entire body in order to counteract chronic diseases such as type II diabetes, cardiovascular diseases, and cancer.
Manuela Cervelli +5 more
doaj +5 more sources
Oxidation of spermine by an amine oxidase from lentil seedlings [PDF]
Plant Physiology, 1991 Spermine is a substrate of lentil (Lens culinaris) seedling amine oxidase and the oxidation products are reversible inactivators of the enzyme. The spermine is oxidized at the terminal amino groups to a dialdehyde: 2 moles of hydrogen peroxide and 2 ...
COGONI A +4 more
core +3 more sources
PLoS ONE, 2013 Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal. Spermine oxidase is highly expressed in the mouse brain and plays a key role in regulating the
Manuela Cervelli +12 more
doaj +3 more sources
Heterologous expression and characterization of mouse spermine oxidase RID A-4573-2009 [PDF]
Journal of Biological Chemistry, 2003 Polyamine oxidases are key enzymes responsible of the polyamine interconversion metabolism in animal cells. Recently, a novel enzyme belonging to this class of enzymes has been characterized for its capability to oxidize preferentially spermine and ...
MARIOTTINI, Paolo +3 more
core +5 more sources
Spermine Synthase at the Polyamine–Redox Interface: Mechanistic Evidence from Snyder–Robinson Syndrome and Cancer [PDF]
AntioxidantsPolyamines are essential metabolites whose biological effects depend on the balance among putrescine, spermidine, and spermine. Spermine synthase (SMS) catalyzes the terminal step of mammalian spermine biosynthesis, simultaneously consuming spermidine ...
Ziling Lin +5 more
doaj +2 more sources
Glutamate Excitotoxicity Linked to Spermine Oxidase Overexpression
Molecular Neurobiology, 2018 Excitotoxic stress has been associated with several different neurological disorders, and it is one of the main causes of neuronal degeneration and death.
Alessia Leonetti, Roberta Mastrantonio
core +4 more sources
Targeting Spermine Oxidase to Mitigate Traumatic Brain Injury Pathology in the Aging Brain [PDF]
AntioxidantsTraumatic brain injury (TBI) in the elderly is frequently associated with worsened neurological outcomes and prolonged recovery, yet the age-specific molecular mechanisms driving this vulnerability remain poorly understood.
Jui-Ming Sun +6 more
doaj +2 more sources
Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection [PDF]
Frontiers in Immunology, 2018 Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine.
Alain P. Gobert +27 more
doaj +2 more sources
Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
doaj +2 more sources
Amino Acids, 2016 Spermine oxidase (SMOX) is a flavin-containing enzyme that specifically oxidizes spermine to produce spermidine, 3-aminopropanaldehyde and hydrogen peroxide.
LEONETTI, ALESSIA +16 more
core +4 more sources