miR-139-5p Suppresses Hepatocellular Carcinoma Progression by Targeting SMOX to Inhibit AKT-mTOR Pathway and Epithelial-Mesenchymal Transition [PDF]
Scientific ReportsThis study investigates the tumor-suppressive role of miR-139-5p in hepatocellular carcinoma (HCC) and its molecular mechanism of regulating the AKT-mTOR signaling pathway through targeting spermidine oxidase (SMOX). Analysis of TCGA and UALCAN databases
Wenjun Pei, Qianqian Zhao
exaly +7 more sources
Metabolism-Related Genes SMOX and SUCLG2 as Immunological and Prognostic Biomarkers in Colorectal Cancer: A Pan-Cancer Analysis [PDF]
Current Issues in Molecular BiologyExpression patterns and underlying mechanisms of metabolism-related genes SMOX and SUCLG2 in pan-cancer remain unclear. We conducted a comprehensive pan-cancer analysis of SMOX and SUCLG2, to explore their potential roles and mechanisms of action ...
Zuming Xiong +5 more
exaly +7 more sources
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors
Medical Sciences, 2022 The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine
Robert A Casero +2 more
exaly +6 more sources
Targeting SMOX Preserves Optic Nerve Myelin, Axonal Integrity, and Visual Function in Multiple Sclerosis [PDF]
BiomoleculesMultiple sclerosis (MS) is a highly disabling chronic neurological condition affecting young adults. Inflammation, demyelination, and axonal damage are key pathological features of MS and its animal model, experimental autoimmune encephalomyelitis (EAE).
Harry O. Henry-Ojo +2 more
doaj +5 more sources
Advanced ScienceThe modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation and progression of various tumor types. However, the precise role and potential mechanism of Y‐box‐binding protein 1 (YBX1) in esophageal squamous cell carcinoma ...
Ranran Sun, Yawen Zou
exaly +4 more sources
CellsDiabetic retinopathy, a major cause of vision loss, is characterized by neurovascular changes in the retina. The lack of effective treatments to preserve vision in diabetic patients remains a significant challenge.
S Priya Narayanan +2 more
exaly +6 more sources
Heterophyllin B ameliorates diabetic lower limb ischemia by inhibiting SMOX to activate the Nrf2 antioxidant pathway [PDF]
Chinese MedicineBackground Diabetic lower limb ischemia (DLLI) is a serious complication of diabetes with limited therapeutic options. Heterophyllin B (HET-B), a bioactive cyclopeptide from Pseudostellaria heterophylla, possesses antioxidant properties.
Shudong Lin +13 more
doaj +5 more sources
Low Ankle-Brachial Index in Patients on Hemodialysis Is Associated with Elevated Serum Levels of Spermine Oxidase and C-Reactive Protein [PDF]
LifePeripheral arterial disease (PAD) is a major cardiovascular complication of hemodialysis (HD), during which inflammation and oxidative stress contribute to vascular injury.
Yahn-Bor Chern +5 more
doaj +2 more sources
Targeting Spermine Oxidase to Mitigate Traumatic Brain Injury Pathology in the Aging Brain [PDF]
AntioxidantsTraumatic brain injury (TBI) in the elderly is frequently associated with worsened neurological outcomes and prolonged recovery, yet the age-specific molecular mechanisms driving this vulnerability remain poorly understood.
Jui-Ming Sun +6 more
doaj +2 more sources
NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein [PDF]
Scientific ReportsPolyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at the mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e.
Tomoaki Hirakawa +7 more
doaj +2 more sources