Results 31 to 40 of about 2,201 (173)

Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation

Frontiers in Cell and Developmental Biology, 2023
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis.
Clara Perrone, Clara Perrone, Silvia Pomella, Silvia Pomella, Matteo Cassandri, Matteo Cassandri, Michele Pezzella, Stefano Giuliani, Tecla Gasperi, Tecla Gasperi, Antonella Porrazzo, Antonella Porrazzo, Anna Alisi, Anna Pastore, Silvia Codenotti, Alessandro Fanzani, Giovanni Barillari, Libenzio Adrian Conti, Biagio De Angelis, Concetta Quintarelli, Concetta Quintarelli, Paolo Mariottini, Franco Locatelli, Franco Locatelli, Francesco Marampon, Rossella Rota, Manuela Cervelli   +26 more
doaj   +1 more source

37161 Triazole-based reversible inhibitors of spermine oxidase and implications for amelioration of neuronal injury

Journal of Clinical and Translational Science, 2021
IMPACT: This project aims to investigate the impact of spermine oxidase inhibition on amelioration of neuronal injury. OBJECTIVES/GOALS: Our group has recently described a series of triazole-based reversible inhibitors of spermine oxidase (SMOX ...
Amelia Furbish, Patrick Woster
doaj   +1 more source

Treatment with MDL 72527 Ameliorated Clinical Symptoms, Retinal Ganglion Cell Loss, Optic Nerve Inflammation, and Improved Visual Acuity in an Experimental Model of Multiple Sclerosis

Cells, 2022
Multiple Sclerosis (MS) is a highly disabling neurological disease characterized by inflammation, neuronal damage, and demyelination. Vision impairment is one of the major clinical features of MS.
Fang Liu, Moaddey Alfarhan, Leanna Baker, Nidhi Shenoy, Yini Liao, Harry O. Henry-Ojo, Payaningal R. Somanath, S. Priya Narayanan   +7 more
doaj   +1 more source

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis. [PDF]

Invest Ophthalmol Vis Sci
Visual dysfunction due to optic neuritis (ON) is an early clinical manifestation of multiple sclerosis (MS). ON is characterized by inflammation of the optic nerve, demyelination, axonal damage, and retinal ganglion cell (RGC) loss. Previously, we showed that spermine oxidase (SMOX), a polyamine catabolizing enzyme, modulates visual function in an ...
Henry Ojo H, Liu F, Alanazi AH, Zahedi KA, Soleimani M, Zhang D, Somanath PR, Narayanan SP.   +7 more
europepmc   +3 more sources

Phosphatase of Regenerating Liver-1 Regulates Wing Vein Formation through TGF-β Pathway in Drosophila melanogaster

Frontiers in Bioscience-Landmark, 2022
Background: Drosophila Phosphatase of Regenerating Liver-1 (PRL-1) is the only homolog of the mammalian PRLs with which it shares high sequence and structural similarities.
Huimei Zheng, Ziwei Lou, Xin Yuan, Haoyue Wu, Xiaohang Yang, Yongmei Xi   +5 more
doaj   +1 more source

SmOx Differential Division.

, 2022
SmOx cells were plated in 100×100×5 μm wells and imaged with a 20×/0.8 NA lens. DIC images were captured every 10 min for 24 h. Video depicts images shown in Fig 2. Video is presented at 2.5 frames per second. (AVI)
Lars D. Renner (11188146), Christopher L. de Graffenried (2991261), Thomas E. Sladewski (10826547), Richard S. Muniz (11965421), Paul C. Campbell (11965424)   +4 more
core   +1 more source

A novel ZNF263-SMOX-ROS-TRIB3 signaling axis drives Wnt/β-catenin activation and metastatic progression in colorectal cancer. [PDF]

Apoptosis
Spermine oxidase (SMOX), a key enzyme in polyamine catabolism, has been increasingly linked to tumor progression. However, its regulatory network and biological significance in colorectal cancer (CRC), particularly in metastasis, remain largely undefined.
Sun L, Zhang Y, Zhang X, Zhou J, Ji L, Li R, Zhao S, Fu Y, Wang J, Tang M, Wang W, Qian C, Sun Q, Wang D.   +13 more
europepmc   +4 more sources

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Journal of Neuroinflammation, 2020
Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored.
Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani   +14 more
doaj   +1 more source

Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures

Biomolecules, 2022
Polyamines are organic polycations ubiquitously present in living cells. Polyamines are involved in many cellular processes, and their content in mammalian cells is tightly controlled.
Manuela Marcoli, Chiara Cervetto, Sarah Amato, Cristian Fiorucci, Guido Maura, Paolo Mariottini, Manuela Cervelli   +6 more
doaj   +1 more source

TOEFAZ1 RNAi and SmOx Sentinel.

, 2022
TOEFAZ1-RNAi and SmOx mClv3-sentinel cells were induced for 16 h prior to plating in 100×100×5 μm wells. Split-view system allows for simultaneous capture of DIC and FITC images. Images were taken every 10 min for 20 h with a 40×/1.3 NA oil lens using 30
Lars D. Renner (11188146), Christopher L. de Graffenried (2991261), Thomas E. Sladewski (10826547), Richard S. Muniz (11965421), Paul C. Campbell (11965424)   +4 more
core   +1 more source