Advanced ScienceDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Dan Luo +13 more
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Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
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Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson’s Disease [PDF]
npj Parkinson's DiseaseParkinson’s Disease (PD) is a neurodegenerative disorder characterized by α-synuclein accumulation and aggregation, leading to disrupted cellular homeostasis, impaired mitochondrial function, and neuroinflammation, ultimately causing neuronal death ...
Bedri Ranxhi +7 more
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Prognostic poteintial of polyamine metabolism-related genes in hepatocellular carcinoma [PDF]
Scientific ReportsThis study aimed to identify and validate prognostic genes associated with polyamine metabolism-related genes (PMRGs) in hepatocellular carcinoma (HCC), offering potential novel therapeutic targets and strategies.
Wei Zheng +7 more
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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk.
Enhui Li +11 more
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Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation. [PDF]
J Cell Mol MedABSTRACTThe effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength and wire‐grip tests.
Zhou Y +9 more
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Alterations of renal polyamine metabolism in mice with folic acid-induced chronic kidney disease [PDF]
Biochemistry and Biophysics ReportsChronic kidney disease (CKD) often follows acute kidney injury, leading to renal fibrosis and progressive renal failure. Spermine, a polyamine with antioxidant and anti-inflammatory properties, helps reduce renal fibrosis and may serve as a biomarker for
Cheng Xue +4 more
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SMOX expression predicts the prognosis of non-small cell lung cancer [PDF]
Annals of Translational Medicine, 2021 The development of non-small cell lung cancer (NSCLC) is very rapid, and the effect of its treatment is often closely related to the diagnosis time of the disease. Therefore, simple and convenient tumor biomarkers are helpful for the timely diagnosis and prevention of NSCLC.Through univariate and multivariate Cox regression analyses, SMOX was ...
Huang, Zhanghao +4 more
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SMOX and SMS Responsible for Polyamine Metabolism Enhanced Adipogenesis [PDF]
, 2021 Abstract Adipose tissue regulating carbohydrate and lipid metabolism had been extensively focused. However, the regulation of amino acid metabolism during adipocyte differentiation remained detailed. Here we applied RNA-Seq technique to establish the transcriptional landscapes of amino acid metabolism during adipogenesis. We totally screened 17
Xia Yi +5 more
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PLoS ONE, 2022 The enzyme spermine oxidase (SMOX) is involved in polyamine catabolism and converts spermine to spermidine. The enzymatic reaction generates reactive hydrogen peroxide and aldehydes as by-products that can damage DNA and other biomolecules.
Armand W J W Tepper +5 more
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