Results 11 to 20 of about 2,201 (173)
Journal of Integrative NeuroscienceBackground:Stroke is a major cause of morbidity and mortality, characterized by neuronal damage and complex cell death pathways. This study aimed to investigate the protective role of spermine oxidase (Smox) in ischemic stroke and its effect on neuronal ...
Zhihui Li +14 more
doaj +4 more sources
Spermine Oxidase–Substrate Electrostatic Interactions: The Modulation of Enzyme Function by Neighboring Colloidal ɣ-Fe2O3 [PDF]
Biomolecules, 2023 Protein–nanoparticle hybridization can ideally lead to novel biological entities characterized by emerging properties that can sensibly differ from those of the parent components.
Graziano Rilievo +11 more
doaj +3 more sources
Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation [PDF]
Biomolecules, 2021 Background: In the brain, polyamines are mainly synthesized in neurons, but preferentially accumulated in astrocytes, and are proposed to be involved in neurodegenerative/neuroinflammatory disorders and neuron injury.
Chiara Cervetto +11 more
doaj +2 more sources
Biomedicines, 2022 Uncovering tumor markers of colorectal cancer is important for the early detection and prognosis of the patients. Spermine oxidase (SMOX) is upregulated in various cancers.
Sooyoun Kim +11 more
doaj +2 more sources
SMOX is differentially expressed in central nervous system metastasis in human breast cancer.
, 2023 Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that spermine oxidase, encoded by
Shahan Mamoor
core +3 more sources
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study [PDF]
Scientific Reports, 2021 Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention ...
João Fadista +17 more
doaj +2 more sources
Targeting Polyamine Metabolism in Colorectal Cancer: Apigenin Dismantles the HIF-1α/SMOX Positive Feedback Loop to Suppress Tumor Progression [PDF]
International Journal of Molecular SciencesTumor microenvironments, particularly hypoxia and inflammation, heavily influence colorectal cancer (CRC) pathogenesis by altering polyamine metabolism. Identifying natural compounds targeting these vulnerabilities remains critical. Integrating untargeted metabolomics, network pharmacology, and a human endogenous metabolite library screen, we ...
Lihong Chen, Ji Liu, Zhengkun Zhang
exaly +4 more sources
Frontiers in Immunology, 2018 Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine.
Alain P. Gobert +27 more
doaj +2 more sources
Road Map of Semiconductor Metal-Oxide-Based Sensors: A Review
Sensors, 2023 Identifying disease biomarkers and detecting hazardous, explosive, flammable, and polluting gases and chemicals with extremely sensitive and selective sensor devices remains a challenging and time-consuming research challenge.
Taposhree Dutta +3 more
doaj +3 more sources
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and ...
Maria Luisa Di Paolo +10 more
doaj +2 more sources