Results 51 to 60 of about 2,201 (173)

Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents

Molecules, 2022
Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure–activity relationship study of the PG11047
Diptesh Sil, Sudipta Panja, Chinmay M. Jogdeo, Raj Kumar, Ao Yu, Cassandra E. Holbert, Ling Ding, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero, David Oupický   +10 more
doaj   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Influence of Conduction Mechanism Changes on the Sensor Performance of SMOX Based Gas Sensors

Procedia Engineering, 2014
AbstractDC electrical resistance measurements on undoped polycrystalline SnO2 thick film sensing layers are performed to check if, under CO exposure in realistic application conditions (dry or humid air), a change in conduction mechanism is possible. The results show for CO concentrations below 250ppm in dry air, that the conduction through the sensing
Rebholz, J., Weimar, U., Barsan, N.
openaire   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, Volume 13, Issue 61, 3 November 2026.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1 alpha Signaling in Retinal Glial Cells under Hypoxic Conditions

, 2020
PURPOSE. Acrolein, a highly reactive unsaturated aldehyde, is known to facilitate glial cell migration, one of the pathological hallmarks in diabetic retinopathy. However, cellular mechanisms of acrolein generation in retinal glial cells remains elusive.
Noda, Kousuke, Liu, Ye, Kanda, Atsuhiro, Wu, Di, Ishida, Susumu, Murata, Miyuki   +5 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

H2S Sensing with SnO2‐Based Gas Sensors: Sulfur Poisoning Mechanism Revealed by Operando DRIFTS and DFT Calculations

Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.
The formation of sticky sulfite and sulfate surface species is identified as the root cause of the poisoning effect of H2S on SnO2‐based sensors by the compelling results and detailed analyses from operando DRIFTS experiments and density functional theory (DFT) calculations.
Tingqiang Yang, Matthias Boepple, Anne Hémeryck, Antoine Jay, Sara Karwounopoulos, Udo Weimar, Nicolae Barsan   +6 more
wiley   +2 more sources

Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine

Medical Sciences, 2018
Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle health and function is essential for the entire body in order to counteract chronic diseases such as type II diabetes, cardiovascular diseases, and cancer.
Manuela Cervelli, Alessia Leonetti, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Paolo Mariottini   +5 more
doaj   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source