Results 71 to 80 of about 2,201 (173)

Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Patients with proliferative diabetic retinopathy show elevated vitreous levels of the acrolein adduct FDP‐lys and CCL2. In rat Müller glial cells (TR‐MUL5), acrolein increases Ccl2 gene expression and CCL2 secretion and promotes macrophage migration.
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Kousuke Noda, Susumu Ishida   +4 more
wiley   +1 more source

Immunization peptides.

, 2022
Structural model of human SMOX and immunization peptides.
Vincent N. A. Klaren (12446918), Jay H. Kalin (1310334), Patricia Molina-Ortiz (167505), Gerald Chu (12446915), Antonietta Impagliazzo (244527), Armand W. J. W. Tepper (12446912)   +5 more
core   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Understanding the Sensing Mechanism of Rh₂O₃ loaded In₂O₃

Proceedings, 2018
The effect of Rh loading on CO sensing was studied for the case of In2O3. This was done by performing measurements with sensors based on loaded and unloaded materials that were performed at an operation temperature of 300 °C in the presence of low ...
Inci Boehme, Sina Herrmann, Anna Staerz, Helena Brinkmann, Udo Weimar, Nicolae Barsan   +5 more
doaj   +1 more source

NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA

Advanced Science, Volume 12, Issue 31, August 21, 2025.
Zhan et al. demonstrate the vital role of NAT10‐catalyzed ac4C modification in regulating autophagy‐associated lysosomal acidification. They uncover the clinical and biological significance of ATP6V0E1, an important v‐ATPase assembly subunit, in tumor metastasis, particularly in the malignant progression of ESCC.
Yu‐Juan Zhan, Chun‐Miao Deng, Lin Tang, Shu‐Jun Li, Tao‐Yang Xu, Xian Wei, Xin‐Yi Zhang, Can‐Can Zheng, Li Deng, Cui Shao, Zhong‐Min Ouyang, Alfred King‐Yin Lam, Rong Zhang, Jun Liu, Xing‐Yuan Shi, Zhen‐Yu Pan, Wei Dai, Ming‐Liang He, Simon Law, Xu Li, Xiao‐Bing Chen, Cheng Zhou, Bin Li, Wen‐Wen Xu   +23 more
wiley   +1 more source

Ammonia Dynamics in the Human Body: Insights in Biomedical Sensing Technologies

Advanced Sensor Research, Volume 4, Issue 7, July 2025.
Ammonia (NH3) is a significant biomarker in diagnostics, affecting the respiratory system, stomach, liver, kidneys, bladder, and gastrointestinal tract. NH3 detection, using sensors, has the potential to improve medical diagnosis. This review examines recent advancements in NH3 sensing technologies and explores future research directions, including ...
Annelot Nijkoops, Manuela Ciocca, Martina Aurora Costa Angeli, Silvia Pogliaghi, Soufiane Krik, Enrico Avancini, Niko Münzenrieder, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

TGFβ receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis

Developmental Biology, 2007
Elucidating the regulatory mechanism of cell proliferation is central to the understanding of cancer development or organ size control. Drosophila spermatogenesis provides an excellent model to study cell proliferation since the germline cells mitotically amplify in a precise manner. However, the underlying molecular mechanism remains elusive.
Li, Chun-Yan, Guo, Zheng, Wang, Zhaohui
openaire   +2 more sources

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, Volume 24, Issue 6, June 2025.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Spectroscopic and calorimetric characterization of spermine oxidase and its association forms

, 2017
Spermine oxidase (SMOX) is a flavin-containing enzyme that oxidizes spermine to produce spermidine, 3-aminopropanaldehyde and hydrogen peroxide. SMOX has been shown to play key roles in inflammation and carcinogenesis; indeed it is differentially ...
Cervelli, Manuela, Alessia Leonetti, Leonetti, Alessia, YURTSEVER, ZULEYHA NIHAN, Enzo Agostinelli, Yuta Kanamori, Polticelli, Fabio, Laura Cervoni, Agostinelli, Enzo, Fabio Polticelli, KANAMORI, YUTA, Mariottini, Paolo, Stano, Pasquale, Manuela Cervelli, Paolo Mariottini, Cervoni, Laura, Zuleyha Nihan Yurtsever, Pasquale Stano   +17 more
core   +1 more source

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source