Results 61 to 70 of about 2,201 (173)

Monocyte Single‐Cell‐Type Gene Expression Analysis Differentiates Kawasaki Disease From Viral Infection With High Specificity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Kawasaki disease (KD) and viral infection (VD) share similar clinical features but require distinct treatments. A practical biomarker to distinguish them is therefore clinically important. Previous blood transcriptome studies identified many differentially expressed genes, but large gene panels are impractical for routine laboratories. A ratio‐
Nelson L. S. Tang, Tsz‐Ki Kwan, Assunta C. H. Ho, Hugh Simon Lam, Geoffrey Mok, Dan Huang, Suk‐Ling Ma, Kwong‐Sak Leung   +7 more
wiley   +1 more source

434 In silico ADMET optimization and preliminary biologic activity of novel spermine oxidase inhibitors as neuroprotective agents

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The goal of this project was to conduct a preliminary assessment of in vivo feasibility early on in the drug-discovery process in an effort to expedite the translation of novel drug scaffolds to potential clinical candidates.
Amelia B Furbish, Pieter Burger, Yuri K Peterson, Patrick M Woster   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Selectivity Enhancement by Using Double-Layer MOX-Based Gas Sensors Prepared by Flame Spray Pyrolysis (FSP)

Sensors, 2016
Here we present a novel concept for the selective recognition of different target gases with a multilayer semiconducting metal oxide (SMOX)-based sensor device.
Julia Rebholz, Katharina Grossmann, David Pham, Suman Pokhrel, Lutz Mädler, Udo Weimar, Nicolae Barsan   +6 more
doaj   +1 more source

The effects of SMOX induction by curcumin on DNA damage and growth inhibition.

, 2018
(A) AGS cells were treated for 48 h with curcumin in the presence or absence of 250 μM MDL72527, a polyamine oxidase inhibitor. (B) SMOX knockout or control AGS cells were treated for 48 h with increasing concentrations of curcumin. Lysates were analyzed
Yuan Lui (5680445), Matthew Dunworth (4424164), Robert A. Casero Jr (178905), Tracy Murray-Stewart (659215), Patrick M. Woster (1305114), Francis M. Giardiello (5680448)   +5 more
core   +1 more source

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, Volume 78, Issue 2, Page 449-462, February 2026.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Application Runs the Show: What Can We Learn about the Future from the Past?

Proceedings, 2019
SMOX-based sensors appeared as a response to a very serious safety issue in Japan, namely gas explosion accidents related to leakages of piped and bottled cooking gas. […]
Nicolae Barsan
doaj   +1 more source

Inactivation of genes in Activin signaling (daw, Smox and babo) in muscle, but not in fat body extended lifespan.

, 2013
(A) Tissue-specific gene expression pattern of daw. (B) Tissue-specific distribution of transcription factor Smox using 7-day-old Oregon R females. (C–E) Lifespan analysis of Activin signaling using muscle-specific Gal4 driver (MHC-Gal4).
Ping Kang (300222), Marc Tatar (68517), Ana Maria Hernandez (481014), Hua Bai (145775)   +3 more
core   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.

PLoS ONE, 2017
Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with ...
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R Doherty, Mark A Hall, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleimani   +12 more
doaj   +1 more source