Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix [PDF]
Int J Mol Sci, 2022 Polyamine oxidase (PAOX) (N1-acetylpolyamine oxidase) is a major enzyme in the polyamine catabolism pathway that generates hydrogen peroxide. Hydrogen peroxide plays a crucial role in skin aging via extracellular matrix (ECM) degradation by increasing ...
Hae Dong Jeong +7 more
core +2 more sources
Effect of Temperature on Polyamine Oxidase Genes in Skeletonema dohrnii [PDF]
Int J Mol SciIn our experiments, we investigated the effect of temperature on diatom polyamine metabolism using Skeletonema dohrnii as an experimental algal species. We set three different temperature conditions for incubation and selected Skeletonema dohrnii in the ...
Wei Teng, Jun Sun
core +2 more sources
A Novel Polyamine Oxidase from Kluyveromyces marxianus with Potential for Total Polyamine Determination [PDF]
BioTechPolyamines and their acetylated derivatives are promising biomarkers for noninvasive cancer diagnostics, creating demand for robust enzymatic tools for their detection.
Egor P. Sergeev, Denis L. Atroshenko
doaj +2 more sources
Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration [PDF]
Frontiers in Neuroscience, 2019 Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative ...
Prahalathan Pichavaram +20 more
doaj +2 more sources
Alterations of renal polyamine metabolism in mice with folic acid-induced chronic kidney disease
Biochemistry and Biophysics ReportsChronic kidney disease (CKD) often follows acute kidney injury, leading to renal fibrosis and progressive renal failure. Spermine, a polyamine with antioxidant and anti-inflammatory properties, helps reduce renal fibrosis and may serve as a biomarker for
Cheng Xue +4 more
doaj +2 more sources
Defining novel plant polyamine oxidase subfamilies through molecular modeling and sequence analysis [PDF]
BMC Evolutionary Biology, 2019 Background The polyamine oxidases (PAOs) catabolize the oxidative deamination of the polyamines (PAs) spermine (Spm) and spermidine (Spd). Most of the phylogenetic studies performed to analyze the plant PAO family took into account only a limited number ...
Cesar Daniel Bordenave +4 more
doaj +2 more sources
Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
doaj +2 more sources
The immunological effects of the polyamine oxidase enzyme partially cleared from the cerebrospinal fluid against secondary secondary cystitis in white mice. Coagulation factor and delayed hypersensitivity [PDF]
مجلة التربية والعلم, 2007 The study included immune response to infection with secondary hydatid disease in BALB/c mice activated by partially purified cerebrospinal fluid-polyamine oxidase (CSF-PAO) with spermine and infected with protoscoleces of Echinococcus granulosus.
Khawla Al-Flaeh, Asmaa Ali, Wathba Ali
doaj +1 more source
Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]
, 2008 The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Perchet, Geoffrey-Thibault +7 more
core +1 more source
Semicarbazide diminishes the signs of bleomycin-induced pulmonary fibrosis in rats [PDF]
The Ukrainian Biochemical Journal, 2021 The pathogenesis of pulmonary fibrosis (PF) is accompanied by extracellular matrix (ECM) deposition, oxidative stress, and inflammation progression, as well as hyperactivation of amine oxidases (AOs), which contribute to disease manifestation.
O. O. Hudkova +5 more
doaj +1 more source