Results 311 to 320 of about 310,272 (392)

Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders

The Journal of Physiology, EarlyView.
Abstract figure legend The carotid body develops aberrant high activity in chronic heart failure, resistant hypertension, obstructive sleep apnoea (OSA) and diabetes. Hyperactivity of the carotid body leads to both high tonicity and increased sensitivity of the arterial chemoreflex with resultant sympathoexcitation.
Tymoteusz Żera, Bartłomiej Paleczny, Maciej Siński, Sílvia V. Conde, Krzysztof Narkiewicz, Piotr Ponikowski, Julian F.R. Paton, Piotr Niewiński   +7 more
wiley   +1 more source

Bacillus thuringiensis Cry1A Insecticidal Toxins and Their Digests Do Not Stimulate Histamine Release from Cultured Rat Mast Cells. [PDF]

Biology (Basel)
Ohto H, Ohno M, Suganuma-Katagiri M, Hara T, Egawa Y, Tomimoto K, Haginoya K, Hori H, Iwamoto Y, Hayakawa T.   +9 more
europepmc   +1 more source

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications

The Journal of Physiology, EarlyView.
Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh, Ming Chuen Chong, Alexander D. Miras, Carel W. le Roux   +3 more
wiley   +1 more source

Histamine-modulated wettability switching in G-protein-coupled receptor inspired nanochannel for potential drug screening and biosensing. [PDF]

Nat Commun
Zhao Q, Ran XQ, Yan ZY, Qian HL, Yan XP.
europepmc   +1 more source

Long‐term use of low‐dose aspirin for cancer prevention: A 20‐year longitudinal cohort study of 1,506,525 Hong Kong residents

International Journal of Cancer, Volume 156, Issue 12, Page 2330-2339, 15 June 2025.
What's New? Low‐dose aspirin use over an extended period is associated with a reduced risk of colorectal cancer (CRC) and potentially other malignancies. Duration of use to derive such benefits, however, remains unclear. This retrospective study examined low‐dose aspirin use for possible chemoprotective effects among individuals in Hong Kong.
Amy Lam, Ziyu Hao, Karen Yiu, Stephen Chan, Francis Chan, Joseph Sung, Kelvin Tsoi   +6 more
wiley   +1 more source

Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice. [PDF]

Nat Commun
Wen Z, Liu T, Xu X, Acharya N, Shen Z, Lu Y, Xu J, Guo K, Shen S, Zhao Y, Wang P, Li S, Chen W, Li H, Ding Y, Shang M, Guo H, Hou Y, Cui B, Shen M, Huang Y, Pan T, Qingqing W, Cao Q, Wang K, Xiao P.   +25 more
europepmc   +1 more source

Identification of Rubiae Radix et Rhizoma and Its Adulterants Based on “Mass Spectrometry Matrix”

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Galium elegans Wall. in Roxb. (GWR) and Rubia tibetica Hook. f. (RTH) are common adulterants of rubiae radix et rhizoma (RRR). To strengthen RRR adulteration regulation, this paper conducted the adulteration analysis of RRR according to the “mass spectrometry (MS) matrix”.
Xianrui Wang, Minghua Li, Yu Zhang, Jiating Zhang, Wenguang Jing, Xiaohan Guo, Xianlong Cheng, Feng Wei   +7 more
wiley   +1 more source

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition)

Cancer Innovation, Volume 4, Issue 3, June 2025.
ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association   +3 more
wiley   +1 more source

Immunoglobulin‐like transcript 5 polarizes M2‐like tumor‐associated macrophages for immunosuppression in non‐small cell lung cancer

International Journal of Cancer, Volume 156, Issue 11, Page 2225-2236, 1 June 2025.
What's new? Despite advances, the efficacy of current immune checkpoint inhibitor therapies remains suboptimal in non‐small cell lung cancer due to the immunosuppressive tumor microenvironment. Here, ILT5 was found to be highly expressed in tumor‐associated macrophages from non‐small cell lung cancer tissues and associated with poor patient survival ...
Huijun Xu, Xuebing Fu, Shuyun Wang, Yihui Ge, Lu Zhang, Juan Li, Fang Zhang, Yang Yang, Yifu He, Yuping Sun, Aiqin Gao   +10 more
wiley   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
wiley   +1 more source