Histamine pharmacology: from Sir Henry Dale to the 21st century
British Journal of Pharmacology, 2018 Histamine has been one of the most studied substances in medicine, playing a major role in diverse (patho)physiological processes. It elicits its multifaceted modulatory functions by activating four types of GPCRs, designated as H1–4.
E. Tiligada, M. Ennis
semanticscholar +1 more source
The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
doaj +1 more source
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
core +1 more source
Bacterial secretion of histamine within the gut influences immune responses within the lung
Allergy. European Journal of Allergy and Clinical Immunology, 2019 Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express the histidine decarboxylase enzyme (HDC), which is responsible for catalysing the decarboxylation of histidine to histamine.
Weronika Barcik +14 more
semanticscholar +1 more source
HISTAMIN IN THE HYPOPHYSIS [PDF]
The Journal of Nervous and Mental Disease, 1920 n ...
Abel, J. J., Kubota, S.
openaire +3 more sources
Seafood histamine intervention to alcohol intake: regulation, metabolism and control
Human, Health and Halal Metrics, 2020 Background and objective: Seafood have high nutritional value since they contain sufficient amounts of protein, lipid, micronutrients and long-chain polyunsaturated fatty acids, especially omega3 fatty acid.
Leila Peivasteh-Roudsari
doaj +1 more source
Journal of Pharmacological Sciences, 2012 We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H1-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma +3 more
doaj +1 more source
Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review
Brain Sciences, 2023 Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine.
Lingyi Kong +2 more
doaj +1 more source
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
core +1 more source
Histamine food poisonings: A systematic review and meta-analysis
Critical reviews in food science and nutrition, 2018 Objective: The aim of this study was to assess the mean of histamine concentration in food poisoning. Design: Systematic review and meta-analysis of reports published between 1959 and 2013.
F. Colombo +3 more
semanticscholar +1 more source